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  • Kim, Joon TaeChonnam National University (author)

Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial : Rationale and design

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-28
  • SAGE Publications,2023

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1bb31c16-60bd-4567-9d54-23f1b4db4c2c
  • https://lup.lub.lu.se/record/1bb31c16-60bd-4567-9d54-23f1b4db4c2cURI
  • https://doi.org/10.1177/17474930231168742DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Rationale: The optimal duration of dual antiplatelet therapy (DAPT) with clopidogrel-aspirin for the large artery atherosclerotic (LAA) stroke subtype has been debated. Aims: To determine whether the 1-year risk of recurrent vascular events could be reduced by a longer duration of DAPT in patients with the LAA stroke subtype. Methods and study design: A total of 4806 participants will be recruited to detect a statistically significant relative risk reduction of 22% with 80% power and a two-sided alpha error of 0.05, including a 10% loss to follow-up. This is a registry-based, multicenter, prospective, randomized, open-label, blinded end point study designed to evaluate the efficacy and safety of a 12-month duration of DAPT compared with a 3-month duration of DAPT in the LAA stroke subtype. Patients will be randomized (1:1) to either DAPT for 12 months or DAPT for 3 months, followed by monotherapy (either aspirin or clopidogrel) for the remaining 9 months. Study outcomes: The primary efficacy outcome of the study is a composite of stroke (ischemic or hemorrhagic), myocardial infarction, and all-cause mortality for 1 year after the index stroke. The secondary efficacy outcomes are (1) stroke, (2) ischemic stroke or transient ischemic attack, (3) hemorrhagic stroke, and (4) all-cause mortality. The primary safety outcome is major bleeding. Discussion: This study will help stroke physicians determine the appropriate duration of dual therapy with clopidogrel-aspirin for patients with the LAA stroke subtype. Trial registration: URL: https://cris.nih.go.kr/cris. CRIS Registration Number: KCT0004407.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kang, JihoonSeoul National University (author)
  • Kim, Beom JoonSeoul National University (author)
  • Kim, Jun YupSeoul National University (author)
  • Han, Moon Ku (author)
  • Cho, Ki Hyun (author)
  • Park, Man Seok (author)
  • Choi, Kang Ho (author)
  • Park, Jong MooEulji University School of Medicine (author)
  • Kang, Kyusik (author)
  • Kim, Yong Soo (author)
  • Lee, Soo Joo (author)
  • Kim, Jae Guk (author)
  • Cha, Jae KwanDong-a University Hospital (author)
  • Kim, Dae HyunDong-a University Hospital (author)
  • Park, Tai Hwan (author)
  • Park, Sang Soon (author)
  • Choi, Jin Kyo (author)
  • Lee, Kyungbok (author)
  • Park, Kwang YeolChung-Ang University (author)
  • Jeong, Hae BongChung-Ang University (author)
  • Lee, Jun (author)
  • Kwon, Doo Hyuk (author)
  • Cho, Yong JinInje University (author)
  • Hong, Keun SikInje University (author)
  • Park, Hong KyunInje University (author)
  • Lee, Byung ChulHallym University (author)
  • Yu, Kyung HoHallym University (author)
  • Oh, Mi SunHallym University (author)
  • Lee, MinwooHallym University (author)
  • Kim, Dong Eog (author)
  • Gwak, Dong Seok (author)
  • Choi, Jay Chol (author)
  • Kim, Joong Goo (author)
  • Kang, Chul Hoo (author)
  • Kwon, Jee HyunUniversity of Ulsan (author)
  • Kim, Wook JooUniversity of Ulsan (author)
  • Shin, Dong Ick (author)
  • Yum, Kyu Sun (author)
  • Sohn, Sung Il (author)
  • Hong, Jeong Ho (author)
  • Park, Hyungjong (author)
  • Kim, ChulhoHallym University (author)
  • Lee, Sang HwaHallym University (author)
  • Lee, Juneyoung (author)
  • Gorelick, Philip B.Northwestern University Feinberg School of Medicine (author)
  • Norrving, BoLund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research,Skåne University Hospital(Swepub:lu)neur-bno (author)
  • Bae, Hee JoonSeoul National University (author)
  • Chonnam National UniversitySeoul National University (creator_code:org_t)

Related titles

  • In:International Journal of Stroke: SAGE Publications18:8, s. 1015-10201747-49301747-4949

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