Search: WFRF:(Karlsson Mattias)
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Coreceptor usage of...
Coreceptor usage of primary HIV type 1 isolates obtained from different lymph node subsets
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Casper, C (author)
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- Mild, Mattias (author)
- Karolinska Institutet,Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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- Jansson, Marianne (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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- Karlsson, A (author)
- Karolinska Institutet
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- Holmberg, V (author)
- Karolinska Institutet
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- Bratt, G (author)
- Karolinska Institutet
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van Paaschen, H (author)
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- Biberfeld, P (author)
- Karolinska Institutet
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Bjorndal, A (author)
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- Albert, J (author)
- Karolinska Institutet
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Popovic, M (author)
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- Fenyö, Eva Maria (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- Mary Ann Liebert Inc, 2005
- 2005
- English.
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In: AIDS Research and Human Retroviruses. - : Mary Ann Liebert Inc. - 1931-8405 .- 0889-2229. ; 21:12, s. 1003-1010
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Biological characteristics of virus quantitatively rescued from different cell types present in lymph nodes of HIV-1-infected individuals in various stages of their disease were determined, not including patients with AIDS defining illness. Viruses were obtained by cocultivation with donor monocyte-derived macrophages and T-lymphocytes and their biological phenotype compared to viruses obtained from the peripheral blood mononuclear cells of the same patient. The biological phenotype was determined on established cell lines (U937-2, CEM, and MT-2) and on the U87.CD4 coreceptor indicator cell lines and variable region 3 (V3) of the envelope was subjected to direct sequencing. All isolates obtained from lymph node subsets used CCR5 as coreceptor. Furthermore, these viruses were also sensitive to inhibition by beta-chemokines as analyzed for viruses of one patient. All 12 V3 regions showed a unique sequence indicating compartmentalization within each patient. The biological phenotype of CCR5-dependent (R5) HIV-1 isolates obtained from PBMC resembles the phenotype of viruses isolated from different lymph node cell subsets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Casper, C
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Mild, Mattias
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Jansson, Mariann ...
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Karlsson, A
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Holmberg, V
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Bratt, G
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show more...
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van Paaschen, H
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Biberfeld, P
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Bjorndal, A
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Albert, J
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Popovic, M
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Fenyö, Eva Maria
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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AIDS Research an ...
- By the university
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Lund University
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Karolinska Institutet