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Negative associatio...
Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset
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- Graham, Jinko (author)
- University of Washington
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- Kockum, Ingrid (author)
- Karolinska Institutet,Karolinska Institute
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- Sanjeevi, Carani B. (author)
- Karolinska Institutet,Karolinska Institute
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- Landin-Olsson, Mona (author)
- Lund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diabetes lab,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Nyström, Lennarth (author)
- Umeå University
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- Sundkvist, Göran (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital
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- Arnqvist, Hans (author)
- Linköping University
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- Blohmé, Göran (author)
- Sahlgrenska University Hospital
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- Lithner, Folke (author)
- Umeå University
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- Littorin, Bengt (author)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups
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- Scherstén, Bengt (author)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups
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- Wibell, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi- o diabetesgr
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- Östman, Jan (author)
- Karolinska University Hospital
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- Lernmark, Åke (author)
- University of Washington
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- Breslow, Norman (author)
- University of Washington
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- Dahlquist, Gisela (author)
- Umeå universitet,Umeå University,Pediatrik
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(creator_code:org_t)
- 2002-02-27
- 1999
- English.
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In: European Journal of Immunogenetics. - : Wiley. - 0960-7420 .- 1365-2370. ; 26, s. 117-
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in population-based Swedish patients and controls aged 0-34 years. The age dependence of HLA-associated relative risks was assessed by likelihood ratio tests of regression parameters in separate logistic regression models for each HLA category. The analyses demonstrated an attenuation with increasing age at onset in the relative risk for the positively associated DQB1*0201-A1*0502/B1*0302-A1*0301 (DQ2/8) genotype (P = 0.02) and the negatively associated DQB1*0602-A1*0102 (DQ6.2) haplotype (P = 0.004). At birth, DQ6.2-positive individuals had an estimated relative risk of 0.03, but this increased to 1.1 at age 35 years. Relative risks for individuals with DQ genotype 8/8 or 8/X or DQ genotype 2/2 or 2/X, where X is any DQ haplotype ether than 2, 8 or 6.2, were not significantly age-dependent. An exploratory analysis of DQ haplotypes other than 2, 8 and 6.2 suggested that the risk of type 1 diabetes increases with age for DQB1*0604-A1*0102 (DQ6.4) and that the peak risk for the negatively associated DQB1*0301-A1*0501 haplotype is at age 18 years. There was also weak evidence that the risk for DQB1*0303-A1*0301 (DQ9), which has a positive association in the Japanese population, may decrease with age. We speculate that HLA-DQ alleles have a significant effect on the rate of beta cell destruction, which is accelerated in DQ2/8-positive individuals and inhibited, but not completely blocked, in DQ6.2-positive individuals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Graham, Jinko
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Kockum, Ingrid
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Sanjeevi, Carani ...
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Landin-Olsson, M ...
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Nyström, Lennart ...
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Sundkvist, Göran
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show more...
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Arnqvist, Hans
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Blohmé, Göran
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Lithner, Folke
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Littorin, Bengt
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Scherstén, Bengt
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Wibell, Lars
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Östman, Jan
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Lernmark, Åke
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Breslow, Norman
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Dahlquist, Gisel ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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European Journal ...
- Eur J Immunogene ...
- By the university
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Lund University
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Umeå University
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Karolinska Institutet
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Uppsala University