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  • Fragoso-Bargas, NicolasOslo university hospital (author)

Cohort profile : Epigenetics in Pregnancy (EPIPREG) - population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-08-13
  • Public Library of Science (PLoS),2021

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  • LIBRIS-ID:oai:lup.lub.lu.se:1d72225c-4343-44d6-bdbc-51fe791ce99b
  • https://lup.lub.lu.se/record/1d72225c-4343-44d6-bdbc-51fe791ce99bURI
  • https://doi.org/10.1371/journal.pone.0256158DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Pregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother's and child's health. Epigenetics in Pregnancy (EPIPREG) is a population-based sample with the aim to study associations between DNA-methylation in pregnancy and cardiometabolic traits in South Asian and European pregnant women and their offspring. This cohort profile paper aims to present our sample with genetic and epigenetic data and invite researchers with similar cohorts to collaborative projects, such as replication of ours or their results and meta-analysis. In EPIPREG we have quantified epigenome-wide DNA methylation in maternal peripheral blood leukocytes in gestational week 28±1 in Europeans (n = 312) and South Asians (n = 168) that participated in the population-based cohort STORK Groruddalen, in Norway. DNA methylation was measured with Infinium MethylationEPIC BeadChip (850k sites), with technical validation of four CpG sites using bisulphite pyrosequencing in a subset (n = 30). The sample is well characterized with few missing data on e.g. genotype, universal screening for gestational diabetes, objectively measured physical activity, bioelectrical impedance, anthropometrics, biochemical measurements, and a biobank with maternal serum and plasma, urine, placenta tissue. In the offspring, we have repeated ultrasounds during pregnancy, cord blood, and anthropometrics up to 4 years of age. We have quantified DNA methylation in peripheral blood leukocytes in nearly all eligible women from the STORK Groruddalen study, to minimize the risk of selection bias. Genetic principal components distinctly separated Europeans and South Asian women, which fully corresponded with the self-reported ethnicity. Technical validation of 4 CpG sites from the methylation bead chip showed good agreement with bisulfite pyrosequencing. We plan to study associations between DNA methylation and cardiometabolic traits and outcomes.

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  • Opsahl, Julia OUniversity of Oslo (author)
  • Kiryushchenko, NadezhdaOslo university hospital (author)
  • Böttcher, YvonneOslo university hospital (author)
  • Lee-Ødegård, SindreUniversity of Oslo (author)
  • Qvigstad, ElisabethOslo university hospital (author)
  • Richardsen, Kåre RønnOslo Metropolitan University (author)
  • Waage, Christin WOslo Metropolitan University (author)
  • Sletner, LineOslo university hospital (author)
  • Jenum, Anne KarenUniversity of Oslo (author)
  • Prasad, Rashmi BLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)med-rpa (author)
  • Groop, Leif CLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)endo-lgr (author)
  • Moen, Gunn-HelenUniversity of Oslo (author)
  • Birkeland, Kåre IOslo university hospital (author)
  • Sommer, ChristineOslo university hospital (author)
  • Oslo university hospitalUniversity of Oslo (creator_code:org_t)

Related titles

  • In:PLoS ONE: Public Library of Science (PLoS)16:8, s. 1-151932-6203

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