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Arsenic trioxide is...
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Pettersson, HelenLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
(författare)
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells.
- Artikel/kapitelEngelska2009
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LIBRIS-ID:oai:lup.lub.lu.se:1dd77707-c732-4167-b1e2-4f73518952d8
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https://lup.lub.lu.se/record/1289772URI
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https://doi.org/10.1158/1535-7163.MCT-08-0595DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118124317URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Small cell lung carcinoma (SCLC) is an extremely aggressive form of cancer and current treatment protocols are insufficient. SCLC have neuroendocrine characteristics and show phenotypical similarities to the childhood tumor neuroblastoma. As multidrug-resistant neuroblastoma cells are highly sensitive to arsenic trioxide (As2O3) in vitro and in vivo, we here studied the cytotoxic effects of As2O3 on SCLC cells. As2O3 induced pronounced cell death in SCLC cells at clinically relevant concentrations, and also at hypoxia. SCLC cells were more sensitive than non-SCLC cells to As2O3. Cell death was mainly due to necrosis, although apoptotic responses were also seen. A significant in vivo effect of As2O3 on SCLC growth was shown in a nude mice-xenograft model, although a fraction of the treated tumor-bearing animals did not respond. The nonresponding SCLC tumors differed in morphology and cell organization compared with treatment-responsive tumors, which in turn, showed decreased vascularization and higher expression of neuroendocrine markers compared with control tumors. Our results suggest a potential clinical application of As2O3 in SCLC therapy. In addition to cell death induction, antiangiogenic induction of differentiation may also be part of the in vivo effect of As2O3 on SCLC growth, as suggested by an increase in neuroendocrine markers in cultured cells.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pietras, AlexanderLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)med-arp
(författare)
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Thorén, MatildaLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)med-mdp
(författare)
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Karlsson, JennyLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)molm-jka
(författare)
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Johansson, LeifLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-ljo
(författare)
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Shoshan, Maria CKarolinska Institutet
(författare)
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Påhlman, SvenLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)molm-spa
(författare)
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Persson, MM
(författare)
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Institutionen för translationell medicinMedicinska fakulteten
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Cancer Therapeutics8:1, s. 160-1701538-85141535-7163
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