WFRF:(Wasserstrom Sebastian)
Sökning: WFRF:(Wasserstrom Sebastian) > (2017) > Two dynamin-like pr...
- Schlimpert, SusanJohn Innes Centre (författare)
Two dynamin-like proteins stabilize FtsZ rings during Streptomyces sporulation
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
- 2017-07-07
- Proceedings of the National Academy of Sciences,2017
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:1e971738-dc75-4b75-9313-03978a9abc8b
- https://lup.lub.lu.se/record/1e971738-dc75-4b75-9313-03978a9abc8bURI
- https://doi.org/10.1073/pnas.1704612114DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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- During sporulation, the filamentous bacteria Streptomyces undergo a massive cell division event in which the synthesis of ladders of sporulation septa convert multigenomic hyphae into chains of unigenomic spores. This process requires cytokinetic Z-rings formed by the bacterial tubulin homolog FtsZ, and the stabilization of the newly formed Z-rings is crucial for completion of septum synthesis. Here we show that two dynamin-like proteins, DynA and DynB, play critical roles in this process. Dynamins are a family of large, multidomain GTPases involved in key cellular processes in eukaryotes, including vesicle trafficking and organelle division. Many bacterial genomes encode dynamin-like proteins, but the biological function of these proteins has remained largely enigmatic. Using a cell biological approach, we show that the two Streptomyces dynamins specifically localize to sporulation septa in an FtsZ-dependent manner. Moreover, dynamin mutants have a cell division defect due to the decreased stability of sporulation-specific Z-rings, as demonstrated by kymographs derived from time-lapse images of FtsZ ladder formation. This defect causes the premature disassembly of individual Z-rings, leading to the frequent abortion of septum synthesis, which in turn results in the production of long spore-like compartments with multiple chromosomes. Two-hybrid analysis revealed that the dynamins are part of the cell division machinery and that they mediate their effects on Z-ring stability during developmentally controlled cell division via a network of protein–protein interactions involving DynA, DynB, FtsZ, SepF, SepF2, and the FtsZ-positioning protein SsgB.
Ämnesord och genrebeteckningar
- NATURVETENSKAP Biologi Mikrobiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Microbiology hsv//eng
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- Bacterial dynamins
- Cell division
- FtsZ
- Sporulation
- Streptomyces
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Wasserstrom, SebastianLund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science(Swepub:lu)cob-saw (författare)
- Chandra, GovindJohn Innes Centre (författare)
- Bibb, Maureen J.John Innes Centre (författare)
- Findlay, Kim C.John Innes Centre (författare)
- Flärdh, KlasLund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science(Swepub:lu)cob-kfl (författare)
- Buttner, Mark J.John Innes Centre (författare)
- John Innes CentreBiologiska institutionen (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences114:30, s. 6176-61830027-8424
- Ingår i:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences114:30, s. 6176-61831091-6490
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