Positive patch test reactions to oxidized limonene: exposure and relevance

Bråred Christensson, Johanna,1965Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institutionen för kemi och molekylärbiologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,Department of Chemistry and Molecular Biology (författare)

Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain, and Sweden. A questionnaire assessing exposure to limonene-containing products was completed. Results. Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. In Barcelona and Copenhagen, >70% of the patients were judged to have had an exposure to limonene assessed as relevant. Conclusions. Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
allergic contact dermatitis
autoxidation
fragrance allergy
hydroperoxide
limonene
oxidation products
patch test
relevance
terpenes

Andersen, Klaus E. (författare)
Bruze, MagnusLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups(Swepub:lu)derm-mbr (författare)
Johansen, Jeanne D. (författare)
Garcia-Bravo, Begona (författare)
Gimenez Arnau, Ana (författare)
Goh, Chee-Leok (författare)
Nixon, Rosemary (författare)
White, Ian R. (författare)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi (creator_code:org_t)

Av författaren/redakt...: Bråred Christens ...; Andersen, Klaus ...; Bruze, Magnus; Johansen, Jeanne ...; Garcia-Bravo, Be ...; Gimenez Arnau, A ...; visa fler...; Goh, Chee-Leok; Nixon, Rosemary; White, Ian R.; visa färre...

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