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  • Russotto, VincenzoSan Luigi University Hospital (author)

Efficacy and adverse events profile of videolaryngoscopy in critically ill patients : subanalysis of the INTUBE study

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1f52dd46-edd4-4c83-8970-9ac594dc4490
  • https://lup.lub.lu.se/record/1f52dd46-edd4-4c83-8970-9ac594dc4490URI
  • https://doi.org/10.1016/j.bja.2023.04.022DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Tracheal intubation is a high-risk procedure in the critically ill, with increased intubation failure rates and a high risk of other adverse events. Videolaryngoscopy might improve intubation outcomes in this population, but evidence remains conflicting, and its impact on adverse event rates is debated. Methods: This is a subanalysis of a large international prospective cohort of critically ill patients (INTUBE Study) performed from 1 October 2018 to 31 July 2019 and involving 197 sites from 29 countries across five continents. Our primary aim was to determine the first-pass intubation success rates of videolaryngoscopy. Secondary aims were characterising (a) videolaryngoscopy use in the critically ill patient population and (b) the incidence of severe adverse effects compared with direct laryngoscopy. Results: Of 2916 patients, videolaryngoscopy was used in 500 patients (17.2%) and direct laryngoscopy in 2416 (82.8%). First-pass intubation success was higher with videolaryngoscopy compared with direct laryngoscopy (84% vs 79%, P=0.02). Patients undergoing videolaryngoscopy had a higher frequency of difficult airway predictors (60% vs 40%, P<0.001). In adjusted analyses, videolaryngoscopy increased the probability of first-pass intubation success, with an OR of 1.40 (95% confidence interval [CI] 1.05–1.87). Videolaryngoscopy was not significantly associated with risk of major adverse events (odds ratio 1.24, 95% CI 0.95–1.62) or cardiovascular events (odds ratio 0.78, 95% CI 0.60–1.02). Conclusions: In critically ill patients, videolaryngoscopy was associated with higher first-pass intubation success rates, despite being used in a population at higher risk of difficult airway management. Videolaryngoscopy was not associated with overall risk of major adverse events. Clinical trial registration: NCT03616054.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Lascarrou, Jean BaptisteNantes University Hospital (author)
  • Tassistro, ElenaUniversity of Milano-Bicocca (author)
  • Parotto, MatteoToronto General Hospital (author)
  • Antolini, LauraUniversity of Milano-Bicocca (author)
  • Bauer, PhilippeMayo Clinic Minnesota (author)
  • Szułdrzyński, KonstantyJagiellonian University (author)
  • Camporota, LuigiGuy's and St Thomas' NHS Foundation Trust (author)
  • Putensen, ChristianUniversity Hospital Bonn (author)
  • Pelosi, PaoloUniversity of Genoa (author)
  • Sorbello, Massimiliano (author)
  • Higgs, Andy (author)
  • Greif, Robert (author)
  • Grasselli, Giacomo (author)
  • Valsecchi, Maria G. (author)
  • Fumagalli, Roberto (author)
  • Foti, Giuseppe (author)
  • Caironi, Pietro (author)
  • Bellani, Giacomo (author)
  • Laffey, John G. (author)
  • Myatra, Sheila N. (author)
  • Spangfors, MartinLund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Center for cardiac arrest,Lund University Research Groups(Swepub:lu)med-ms40 (creator_code:cre_t)
  • San Luigi University HospitalNantes University Hospital (creator_code:org_t)
  • INTUBE study investigators

Related titles

  • In:British Journal of Anaesthesia131:3, s. 607-6160007-0912

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