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Downregulation of A...
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Poza-Guedes, Paloma
(author)
Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy
- Article/chapterEnglish2014
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LIBRIS-ID:oai:lup.lub.lu.se:206dc342-e4fd-46c2-b592-2a58b79d0e10
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https://lup.lub.lu.se/record/4548046URI
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https://doi.org/10.1155/2014/372567DOI
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Language:English
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Summary in:English
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Background. Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy. Methods. We design a prospective longitudinal study (n = 30) with patients with persistent cow's milk proteins (CMP) allergy. After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th-1, Th-2, T-reg, and Th-17 cytokines were also monitored. Results. Baseline levels of PDGF and VEGF in the CMP allergic patients (1170 pg/mL and 253 pg/mL) were different compared to those nonallergic CMP control subjects (501 pg/mL and 108 pg/mL). Both PDGF and VEGF were significantly downregulated (P < 0.05) 6 months after completion of the CMP desensitization process and remained significantly decreased 12 months later. Conclusion. The present study shows a significant increase of PDGF and VEGF in anaphylaxis suffering children compared to a control group. Interestingly, both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization.
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Barrios, Yvelise
(author)
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Fuentes, Victoria
(author)
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Franco, Andres
(author)
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Sanchez-Machin, Inmaculada
(author)
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Alonso, Elena
(author)
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Gonzalez Perez, Ruperto
(author)
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Infante, Sonsoles
(author)
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Zapatero, Lydia
(author)
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Matheu, VictorLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)infl-vmu
(author)
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NeurokirurgiSektion IV
(creator_code:org_t)
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In:BioMed Research International: Hindawi Limited20142314-61332314-6141
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Barrios, Yvelise
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Fuentes, Victori ...
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Franco, Andres
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Sanchez-Machin, ...
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Alonso, Elena
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Gonzalez Perez, ...
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Infante, Sonsole ...
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Zapatero, Lydia
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Matheu, Victor
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