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  • Cadrin-Tourigny, JuliaDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA; Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada,Johns Hopkins Hospital (författare)

Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy : A Multinational Collaboration

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Lippincott Williams & Wilkins,2021
  • 11 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:21046c62-800d-4861-9888-db91f59651c8
  • https://lup.lub.lu.se/record/21046c62-800d-4861-9888-db91f59651c8URI
  • https://doi.org/10.1161/CIRCEP.120.008509DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174517URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Funding agencies: the Canadian Heart Rhythm Society George Mines Traveling Fellowship to Dr Cadrin-Tourigny; the Montreal Heart Institute Foundation Bal du Coeur bursary to Dr Cadrin-Tourigny; The Marvin and Philippa Carsley Chair of medicine to Drs Cadrin-Tourigny, Tadros, and Talajic. The Johns Hopkins Arrhythmogenic Right Ventricular Dysplasia (ARVD) Program is supported by the Dr Francis P. Chiaramonte Private Foundation, the Leyla Erkan Family Fund for ARVD Research, the Dr Satish, Rupal and Robin Shah ARVD Fund at Johns Hopkins, the Bogle Foundation, the Healing Hearts Foundation, the Campanella family, the Patrick J. Harrison Family, the Peter French Memorial Foundation, and the Wilmerding Endowments. The Johns Hopkins ARVD and Zurich ARVC Programs are also supported by a joint grant from the Leonie-Wild Foundation. The Dutch ARVC program is supported by the Dutch Heart Foundation (CVON2018-30 PREDICT2, CVON eDETECT 2015-12) and the Netherlands Organization for Scientific Research (NWO)—travel grant 040.11.586 to Dr James. Dr Asselbergs is supported by UCL Hospitals NIHR biomedical research center. The Zurich ARVC Program is supported by the Georg und Bertha Schwyzer Winiker Foundation, the Baugarten Foundation, and the Swiss Heart Foundation. The Canadian ARVC registry is supported by the Heart in Rhythm Organization (Dr Krahn, Principal Investigator) receiving support from the Canadian Institutes of Health Research (RN380020—406814). The Nordic ARVC registry is supported by the Norwegian Research Council (grant No. 288438, Dr Haugaa), the Swedish Heart-Lung Foundation (grant No. 20180444, Dr Platonov), the Swedish Healthcare system (ALF-grant No. 46702, Dr Platonov and ALF-grant LIO-796561 Dr Svensson). This work is also supported by a grant from the Fondation Leducq to Dr Calkins.
  • Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with ventricular arrhythmias (VA) and sudden cardiac death (SCD). A model was recently developed to predict incident sustained VA in patients with ARVC. However, since this outcome may overestimate the risk for SCD, we aimed to specifically predict life-threatening VA (LTVA) as a closer surrogate for SCD. Methods: We assembled a retrospective cohort of definite ARVC cases from 15 centers in North America and Europe. Association of 8 prespecified clinical predictors with LTVA (SCD, aborted SCD, sustained, or implantable cardioverter-defibrillator treated ventricular tachycardia >250 beats per minute) in follow-up was assessed by Cox regression with backward selection. Candidate variables included age, sex, prior sustained VA (≥30s, hemodynamically unstable, or implantable cardioverter-defibrillator treated ventricular tachycardia; or aborted SCD), syncope, 24-hour premature ventricular complexes count, the number of anterior and inferior leads with T-wave inversion, left and right ventricular ejection fraction. The resulting model was internally validated using bootstrapping. Results: A total of 864 patients with definite ARVC (40±16 years; 53% male) were included. Over 5.75 years (interquartile range, 2.77-10.58) of follow-up, 93 (10.8%) patients experienced LTVA including 15 with SCD/aborted SCD (1.7%). Of the 8 prespecified clinical predictors, only 4 (younger age, male sex, premature ventricular complex count, and number of leads with T-wave inversion) were associated with LTVA. Notably, prior sustained VA did not predict subsequent LTVA (P=0.850). A model including only these 4 predictors had an optimism-corrected C-index of 0.74 (95% CI, 0.69-0.80) and calibration slope of 0.95 (95% CI, 0.94-0.98) indicating minimal over-optimism. Conclusions: LTVA events in patients with ARVC can be predicted by a novel simple prediction model using only 4 clinical predictors. Prior sustained VA and the extent of functional heart disease are not associated with subsequent LTVA events.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bosman, Laurens P.University Medical Center Utrecht,Interuniversity Cardiology Institute of the Netherlands,Netherlands Heart Institute, Netherlands (författare)
  • Wang, WeijiaDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA,Netherlands Heart Institute Department of Cardiology University Medical Center Utrecht, Utrecht University, the Netherlands; Institute of Cardiovascular Science & Institute of Health Informatics, Faculty of Population Health Sciences, University College London, United Kingdom (författare)
  • Tadros, RafikCardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada (författare)
  • Bhonsale, AdityaDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA (författare)
  • Bourfiss, MimountUniversity Medical Center Utrecht,Department of Cardiology, Utrecht University, the Netherlands (författare)
  • Lie, Oyvind H.Norwegian Radium Hospital,Department of Cardiology and Research group for Cardiogenetics and Sudden Cardiac Death, Oslo University Hospital, Rikshospitalet, Norway (författare)
  • Saguner, Ardan M.University Hospital of Zurich,Department of Cardiology, University Heart Center Zurich, Switzerland (författare)
  • Svensson, Anneli,1972-Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA(Swepub:liu)annsv58 (författare)
  • Andorin, AntoineCardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada,Amsterdam UMC, University of Amsterdam, Heart Center, the Netherlands,Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA (författare)
  • Tichnell, CrystalDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA (författare)
  • Murray, BrittneyDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA (författare)
  • Zeppenfeld, KatjaDepartment of Cardiology, Leiden University Medical Center, Netherlands (författare)
  • Van Den Berg, Maarten P.Department of Cardiology, University Medical Center Groningen, University of Groningen, the Netherlands (författare)
  • Asselbergs, Folkert W.University College London,University Medical Center Utrecht,Interuniversity Cardiology Institute of the Netherlands (författare)
  • Wilde, Arthur A.M.Academic Medical Center of University of Amsterdam (AMC) (författare)
  • Krahn, Andrew D.Division of Cardiology, University of British Columbia, Vancouver, Canada (författare)
  • Talajic, MarioCardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada (författare)
  • Rivard, LenaCardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada (författare)
  • Chelko, StephenDepartment of Medicine, Division of Cardiology Johns Hopkins Hospital, Baltimore, USA; Department of Biomedical Sciences, Florida State University College of Medicine, USA,Johns Hopkins Hospital (författare)
  • Zimmerman, Stefan L.The Russell H. Morgan Department of Radiology and Radiological Science , Johns Hopkins Hospital, USA (författare)
  • Kamel, Ihab R.The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, USA (författare)
  • Crosson, Jane E.Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA (författare)
  • Judge, Daniel P.Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA (författare)
  • Yap, Sing ChienErasmus University Medical Center,Department of Cardiology, Erasmus Medical Center, Rotterdam (författare)
  • Van Der Heijden, Jeroen F.Department of Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands (författare)
  • Tandri, HarikrishnaDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, USA (författare)
  • Jongbloed, Jan D.H.Department of Genetics, University Medical Center Groningen, University of Groningen, the Netherlands (författare)
  • Van Tintelen, J. PeterAcademic Medical Center of University of Amsterdam (AMC),Netherlands Heart Institute, University Medical Center Utrecht, Utrecht University, the Netherlands; Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, the Netherlands,Interuniversity Cardiology Institute of the Netherlands (författare)
  • Platonov, Pyotr G.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, USA(Swepub:lu)kard-ppl (författare)
  • Duru, FiratDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA (författare)
  • Haugaa, Kristina H.Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, USA,Norwegian Radium Hospital (författare)
  • Khairy, PaulDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, USA,Montreal Heart Institute (författare)
  • Hauer, Richard N.W.Johns Hopkins Hospital,Interuniversity Cardiology Institute of the Netherlands (författare)
  • Calkins, HughDepartment of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA (författare)
  • Te Riele, Anneline S.J.M.Interuniversity Cardiology Institute of the Netherlands,Johns Hopkins Hospital,University Medical Center Utrecht (författare)
  • James, Cynthia A.Johns Hopkins Hospital (författare)
  • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA; Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, CanadaJohns Hopkins Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Circulation: Arrhythmia and Electrophysiology: Lippincott Williams & Wilkins14:11941-31491941-3084

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