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Sudden Cardiac Deat...
Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy : A Multinational Collaboration
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- Cadrin-Tourigny, Julia (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA; Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada,Johns Hopkins Hospital
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- Bosman, Laurens P. (author)
- Interuniversity Cardiology Institute of the Netherlands,University Medical Center Utrecht,Netherlands Heart Institute, Netherlands
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- Wang, Weijia (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA,Netherlands Heart Institute Department of Cardiology University Medical Center Utrecht, Utrecht University, the Netherlands; Institute of Cardiovascular Science & Institute of Health Informatics, Faculty of Population Health Sciences, University College London, United Kingdom
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- Tadros, Rafik (author)
- Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada
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- Bhonsale, Aditya (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Bourfiss, Mimount (author)
- University Medical Center Utrecht,Department of Cardiology, Utrecht University, the Netherlands
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- Lie, Oyvind H. (author)
- Norwegian Radium Hospital,Department of Cardiology and Research group for Cardiogenetics and Sudden Cardiac Death, Oslo University Hospital, Rikshospitalet, Norway
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- Saguner, Ardan M. (author)
- University Hospital of Zurich,Department of Cardiology, University Heart Center Zurich, Switzerland
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- Svensson, Anneli, 1972- (author)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Andorin, Antoine (author)
- Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada,Amsterdam UMC, University of Amsterdam, Heart Center, the Netherlands,Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Tichnell, Crystal (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Murray, Brittney (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Zeppenfeld, Katja (author)
- Department of Cardiology, Leiden University Medical Center, Netherlands
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- Van Den Berg, Maarten P. (author)
- Department of Cardiology, University Medical Center Groningen, University of Groningen, the Netherlands
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- Asselbergs, Folkert W. (author)
- Interuniversity Cardiology Institute of the Netherlands,University College London,University Medical Center Utrecht
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- Wilde, Arthur A.M. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Krahn, Andrew D. (author)
- Division of Cardiology, University of British Columbia, Vancouver, Canada
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- Talajic, Mario (author)
- Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada
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- Rivard, Lena (author)
- Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, Canada
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- Chelko, Stephen (author)
- Department of Medicine, Division of Cardiology Johns Hopkins Hospital, Baltimore, USA; Department of Biomedical Sciences, Florida State University College of Medicine, USA,Johns Hopkins Hospital
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- Zimmerman, Stefan L. (author)
- The Russell H. Morgan Department of Radiology and Radiological Science , Johns Hopkins Hospital, USA
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- Kamel, Ihab R. (author)
- The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, USA
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- Crosson, Jane E. (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Judge, Daniel P. (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Yap, Sing Chien (author)
- Erasmus University Medical Center,Department of Cardiology, Erasmus Medical Center, Rotterdam
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- Van Der Heijden, Jeroen F. (author)
- Department of Cardiology, University Medical Center Utrecht, Utrecht University, the Netherlands
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- Tandri, Harikrishna (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, USA
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- Jongbloed, Jan D.H. (author)
- Department of Genetics, University Medical Center Groningen, University of Groningen, the Netherlands
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- Van Tintelen, J. Peter (author)
- Interuniversity Cardiology Institute of the Netherlands,Academic Medical Center of University of Amsterdam (AMC),Netherlands Heart Institute, University Medical Center Utrecht, Utrecht University, the Netherlands; Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, the Netherlands
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- Platonov, Pyotr G. (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, USA
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- Duru, Firat (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Haugaa, Kristina H. (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, USA,Norwegian Radium Hospital
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- Khairy, Paul (author)
- Montreal Heart Institute,Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, USA
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- Hauer, Richard N.W. (author)
- Interuniversity Cardiology Institute of the Netherlands,Johns Hopkins Hospital
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- Calkins, Hugh (author)
- Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, USA
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- Te Riele, Anneline S.J.M. (author)
- Johns Hopkins Hospital,University Medical Center Utrecht,Interuniversity Cardiology Institute of the Netherlands
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- James, Cynthia A. (author)
- Johns Hopkins Hospital
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2021
- 2021
- English 11 s.
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In: Circulation: Arrhythmia and Electrophysiology. - : Lippincott Williams & Wilkins. - 1941-3149 .- 1941-3084. ; 14:1
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with ventricular arrhythmias (VA) and sudden cardiac death (SCD). A model was recently developed to predict incident sustained VA in patients with ARVC. However, since this outcome may overestimate the risk for SCD, we aimed to specifically predict life-threatening VA (LTVA) as a closer surrogate for SCD. Methods: We assembled a retrospective cohort of definite ARVC cases from 15 centers in North America and Europe. Association of 8 prespecified clinical predictors with LTVA (SCD, aborted SCD, sustained, or implantable cardioverter-defibrillator treated ventricular tachycardia >250 beats per minute) in follow-up was assessed by Cox regression with backward selection. Candidate variables included age, sex, prior sustained VA (≥30s, hemodynamically unstable, or implantable cardioverter-defibrillator treated ventricular tachycardia; or aborted SCD), syncope, 24-hour premature ventricular complexes count, the number of anterior and inferior leads with T-wave inversion, left and right ventricular ejection fraction. The resulting model was internally validated using bootstrapping. Results: A total of 864 patients with definite ARVC (40±16 years; 53% male) were included. Over 5.75 years (interquartile range, 2.77-10.58) of follow-up, 93 (10.8%) patients experienced LTVA including 15 with SCD/aborted SCD (1.7%). Of the 8 prespecified clinical predictors, only 4 (younger age, male sex, premature ventricular complex count, and number of leads with T-wave inversion) were associated with LTVA. Notably, prior sustained VA did not predict subsequent LTVA (P=0.850). A model including only these 4 predictors had an optimism-corrected C-index of 0.74 (95% CI, 0.69-0.80) and calibration slope of 0.95 (95% CI, 0.94-0.98) indicating minimal over-optimism. Conclusions: LTVA events in patients with ARVC can be predicted by a novel simple prediction model using only 4 clinical predictors. Prior sustained VA and the extent of functional heart disease are not associated with subsequent LTVA events.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- arrhythmogenic right ventricular dysplasia
- calibration
- sudden cardiac death
- syncope
- ventricular tachycardia
- arrhythmogenic right ventricular dysplasia; calibration; sudden cardiac death; syncope; ventricular tachycardia
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Cadrin-Tourigny, ...
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Bosman, Laurens ...
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Wang, Weijia
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Tadros, Rafik
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Bhonsale, Aditya
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Bourfiss, Mimoun ...
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show more...
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Lie, Oyvind H.
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Saguner, Ardan M ...
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Svensson, Anneli ...
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Andorin, Antoine
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Tichnell, Crysta ...
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Murray, Brittney
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Zeppenfeld, Katj ...
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Van Den Berg, Ma ...
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Asselbergs, Folk ...
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Wilde, Arthur A. ...
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Krahn, Andrew D.
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Talajic, Mario
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Rivard, Lena
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Chelko, Stephen
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Zimmerman, Stefa ...
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Kamel, Ihab R.
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Crosson, Jane E.
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Judge, Daniel P.
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Yap, Sing Chien
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Van Der Heijden, ...
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Tandri, Harikris ...
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Jongbloed, Jan D ...
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Van Tintelen, J. ...
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Platonov, Pyotr ...
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Duru, Firat
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Haugaa, Kristina ...
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Khairy, Paul
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Hauer, Richard N ...
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Calkins, Hugh
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Te Riele, Anneli ...
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James, Cynthia A ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation: Arr ...
- By the university
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Lund University
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Linköping University