Resting-state fMRI correlations : From link-wise unreliability to whole brain stability

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The functional architecture of spontaneous BOLD fluctuations has been characterized in detail by numerous studies, demonstrating its potential relevance as a biomarker. However, the systematic investigation of its consistency is still in its infancy. Here, we analyze within- and between-subject variability and test-retest reliability of resting-state functional connectivity (FC) in a unique data set comprising multiple fMRI scans (42) from 5 subjects, and 50 single scans from 50 subjects. We adopt a statistical framework that enables us to identify different sources of variability in FC. We show that the low reliability of single links can be significantly improved by using multiple scans per subject. Moreover, in contrast to earlier studies, we show that spatial heterogeneity in FC reliability is not significant. Finally, we demonstrate that despite the low reliability of individual links, the information carried by the whole-brain FC matrix is robust and can be used as a functional fingerprint to identify individual subjects from the population.

Hindriks, RikkertPompeu Fabra University (författare)
Bettinardi, Ruggero G.Pompeu Fabra University (författare)
Wenger, ElisabethMax Planck Institute for Human Development (författare)
Lisofsky, NinaMax Planck Institute for Human Development,University Medical Center Hamburg-Eppendorf (författare)
Martensson, JohanLund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences,Max Planck Institute for Human Development(Swepub:lu)psyc-jme (författare)
Butler, OisinMax Planck Institute for Human Development (författare)
Filevich, ElisaBernstein Center for Computational Neuroscience Berlin,Humboldt University of Berlin (författare)
Becker, MaxiMax Planck Institute for Human Development,University Medical Center Hamburg-Eppendorf (författare)
Lochstet, MartynaMax Planck Institute for Human Development (författare)
Kühn, SimoneUniversity Medical Center Hamburg-Eppendorf,Max Planck Institute for Human Development (författare)
Deco, GustavoPompeu Fabra University (författare)
Pompeu Fabra UniversityMax Planck Institute for Human Development (creator_code:org_t)

Av författaren/redakt...: Pannunzi, Mario; Hindriks, Rikker ...; Bettinardi, Rugg ...; Wenger, Elisabet ...; Lisofsky, Nina; Martensson, Joha ...; visa fler...; Butler, Oisin; Filevich, Elisa; Becker, Maxi; Lochstet, Martyn ...; Kühn, Simone; Deco, Gustavo; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

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