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  • Tana, ClaudioSs Annunziata Hospital (author)

Prognostic Significance of Chest Imaging by LUS and CT in COVID-19 Inpatients : The ECOVID Multicenter Study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-08-31
  • S. Karger AG,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:2138e8c3-bbf6-42d8-9a61-61990dd32fe9
  • https://lup.lub.lu.se/record/2138e8c3-bbf6-42d8-9a61-61990dd32fe9URI
  • https://doi.org/10.1159/000518516DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Point-of-care lung ultrasound (LUS) score is a semiquantitative score of lung damage severity. High-resolution computed tomography (HRCT) is the gold standard method to evaluate the severity of lung involvement from the novel coronavirus disease (COVID-19). Few studies have investigated the clinical significance of LUS and HRCT scores in patients with COVID-19. Therefore, the aim of this study was to evaluate the prognostic yield of LUS and of HRCT in COVID-19 patients. Methods: We carried out a multicenter, retrospective study aimed at evaluating the prognostic yield of LUS and HRCT by exploring the survival curve of COVID-19 inpatients. LUS and chest CT scores were calculated retrospectively by 2 radiologists with >10 years of experience in chest imaging, and the decisions were reached in consensus. LUS score was calculated on the basis of the presence or not of pleural line abnormalities, B-lines, and lung consolidations. The total score (range 0-36) was obtained from the sum of the highest scores obtained in each region. CT score was calculated for each of the 5 lobes considering the anatomical extension according to the percentage parenchymal involvement. The resulting overall global semiquantitative CT score was the sum of each single lobar score and ranged from 0 (no involvement) to 25 (maximum involvement). Results: One hundred fifty-three COVID-19 inpatients (mean age 65 ± 15 years; 65% M), including 23 (15%) in-hospital deaths for any cause over a mean follow-up of 14 days were included. Mean LUS and CT scores were 19 ± 12 and 10 ± 7, respectively. A strong positive linear correlation between LUS and CT scores (Pearson correlation r = 0.754; R = 0.568; p < 0.001) was observed. By ROC curve analysis, the optimal cut-point for mortality prediction was 20 for LUS score and 4.5 for chest CT score. According to Kaplan-Meier survival analysis, in-hospital mortality significantly increased among COVID-19 patients presenting with an LUS score ≥20 (log-rank 0.003; HR 9.87, 95% CI: 2.22-43.83) or a chest CT score ≥4.5 (HR 4.34, 95% CI: 0.97-19.41). At multivariate Cox regression analysis, LUS score was the sole independent predictor of in-hospital mortality yielding an adjusted HR of 7.42 (95% CI: 1.59-34.5). Conclusion: LUS score is useful to stratify the risk in COVID-19 patients, predicting those that are at high risk of mortality.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ricci, FabrizioLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Casa di Cura Villa Serena di Città Sant'Angelo,University G.d'Annunzio of Chieti-Pescara(Swepub:lu)fa7062ri (author)
  • Coppola, Maria GabriellaOspedale del Mare (author)
  • Mantini, CesareUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Lauretani, FulvioUniversity of Parma,Parma University Hospital (author)
  • Campanozzi, DanieleSan Salvatore Hospital (author)
  • Renda, GiuliaUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Gallina, SabinaUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Lugará, MarinaOspedale del Mare (author)
  • Cipollone, FrancescoUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Giamberardino, Maria AdeleUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Mucci, LucianoSan Salvatore Hospital (author)
  • Ss Annunziata HospitalKardiovaskulär forskning - hypertoni (creator_code:org_t)

Related titles

  • In:Respiration: S. Karger AG101:2, s. 122-1310025-79311423-0356

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