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Alterations in cere...
Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning
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- Jang, David H. (författare)
- University of Pennsylvania
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Piel, Sarah (författare)
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- Greenwood, John C. (författare)
- University of Pennsylvania
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- Kelly, Matthew (författare)
- University of Alabama
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- Mazandi, Vanessa M. (författare)
- The Children's Hospital of Philadelphia
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- Ranganathan, Abhay (författare)
- The Children's Hospital of Philadelphia
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- Lin, Yuxi (författare)
- The Children's Hospital of Philadelphia
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- Starr, Jonathan (författare)
- The Children's Hospital of Philadelphia
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- Hallowell, Thomas (författare)
- The Children's Hospital of Philadelphia
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- Shofer, Frances S. (författare)
- University of Pennsylvania
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- Baker, Wesley B. (författare)
- The Children's Hospital of Philadelphia
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- Lafontant, Alec (författare)
- The Children's Hospital of Philadelphia
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- Andersen, Kristen (författare)
- The Children's Hospital of Philadelphia
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- Ehinger, Johannes K. (författare)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Mitochondrial Medicine,Lund University Research Groups,Skåne University Hospital
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- Kilbaugh, Todd J. (författare)
- The Children's Hospital of Philadelphia
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(creator_code:org_t)
- 2021-02-02
- 2021
- Engelska 9 s.
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Ingår i: Clinical Toxicology. - : Informa UK Limited. - 1556-3650 .- 1556-9519. ; 59:9, s. 801-809
- Relaterad länk:
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: The purpose of this study is the development of a porcine model of carbon monoxide (CO) poisoning to investigate alterations in brain and heart mitochondrial function. Design: Two group large animal model of CO poisoning. Setting: Laboratory. Subjects: Ten swine were divided into two groups: Control (n = 4) and CO (n = 6). Interventions: Administration of a low dose of CO at 200 ppm to the CO group over 90 min followed by 30 min of re-oxygenation at room air. The Control group received room air for 120 min. Measurements: Non-invasive optical monitoring was used to measure cerebral blood flow and oxygenation. Cerebral microdialysis was performed to obtain semi real time measurements of cerebral metabolic status. At the end of the exposure, both fresh brain (cortical and hippocampal tissue) and heart (apical tissue) were immediately harvested to measure mitochondrial respiration and reactive oxygen species (ROS) generation and blood was collected to assess plasma cytokine concentrations. Main results: Animals in the CO group showed significantly decreased Complex IV-linked mitochondrial respiration in hippocampal and apical heart tissue but not cortical tissue. There also was a significant increase in mitochondrial ROS generation across all measured tissue types. The CO group showed a significantly higher cerebral lactate-to-pyruvate ratio. Both IL-8 and TNFα were significantly increased in the CO group compared with the Control group obtained from plasma. While not significant there was a trend to an increase in optically measured cerebral blood flow and hemoglobin concentration in the CO group. Conclusions: Low-dose CO poisoning is associated with early mitochondrial disruption prior to an observable phenotype highlighting the important role of mitochondrial function in the pathology of CO poisoning. This may represent an important intervenable pathway for therapy and intervention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- CNS/psychological
- complications of poisoning
- metabolic
- organ/tissue specific
- other
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Jang, David H.
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Piel, Sarah
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Greenwood, John ...
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Kelly, Matthew
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Mazandi, Vanessa ...
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Ranganathan, Abh ...
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visa fler...
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Lin, Yuxi
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Starr, Jonathan
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Hallowell, Thoma ...
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Shofer, Frances ...
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Baker, Wesley B.
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Lafontant, Alec
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Andersen, Kriste ...
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Ehinger, Johanne ...
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Kilbaugh, Todd J ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Fysiologi
- Artiklar i publikationen
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Clinical Toxicol ...
- Av lärosätet
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Lunds universitet