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The Onset of Molecu...
The Onset of Molecule-Spanning Dynamics in Heat Shock Protein Hsp90
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- Sohmen, Benedikt (författare)
- Albert-Ludwigs University Freiburg,Institute of Physical Chemistry University of Freiburg Albertstrasse 21 79104 Freiburg Germany
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- Beck, Christian (författare)
- Institute of Applied Physics University of Tübingen Auf der Morgenstelle 10 72076 Tübingen Germany;Science Division Institut Max von Laue ‐ Paul Langevin 71 avenue des Martyrs Grenoble 38042 France,Institut Laue Langevin
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- Frank, Veronika (författare)
- Albert-Ludwigs University Freiburg,Institute of Physical Chemistry University of Freiburg Albertstrasse 21 79104 Freiburg Germany
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- Seydel, Tilo (författare)
- Science Division Institut Max von Laue ‐ Paul Langevin 71 avenue des Martyrs Grenoble 38042 France
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- Hoffmann, Ingo (författare)
- Science Division Institut Max von Laue ‐ Paul Langevin 71 avenue des Martyrs Grenoble 38042 France
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- Hermann, Bianca (författare)
- Albert-Ludwigs University Freiburg,Institute of Physical Chemistry University of Freiburg Albertstrasse 21 79104 Freiburg Germany
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- Nüesch, Mark (författare)
- Department of Biochemistry University of Zurich Winterthurerstrasse 190 CH‐8057 Zurich Switzerland
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- Grimaldo, Marco (författare)
- Science Division Institut Max von Laue ‐ Paul Langevin 71 avenue des Martyrs Grenoble 38042 France
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- Schreiber, Frank (författare)
- Institute of Applied Physics University of Tübingen Auf der Morgenstelle 10 72076 Tübingen Germany
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- Wolf, Steffen (författare)
- Albert-Ludwigs University Freiburg,Biomolecular Dynamics, Institute of Physics University of Freiburg Hermann‐Herder‐Strasse 3 79104 Freiburg Germany
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- Roosen-Runge, Felix (författare)
- Malmö universitet,Malmö University,Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Division of Physical Chemistry Lund University Naturvetarvägen 14 22100 Lund Sweden
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- Hugel, Thorsten (författare)
- Albert-Ludwigs University Freiburg,Institute of Physical Chemistry University of Freiburg Albertstrasse 21 79104 Freiburg Germany;Signalling Research Centers BIOSS and CIBSS University of Freiburg Schänzlestrasse 18 79104 Freiburg Germany
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 10:36
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://mau.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Protein dynamics have been investigated on a wide range of time scales. Nano- and picosecond dynamics have been assigned to local fluctuations, while slower dynamics have been attributed to larger conformational changes. However, it is largely unknown how fast (local) fluctuations can lead to slow global (allosteric) changes. Here, fast molecule-spanning dynamics on the 100 to 200 ns time scale in the heat shock protein 90 (Hsp90) are shown. Global real-space movements are assigned to dynamic modes on this time scale, which is possible by a combination of single-molecule fluorescence, quasi-elastic neutron scattering and all-atom molecular dynamics (MD) simulations. The time scale of these dynamic modes depends on the conformational state of the Hsp90 dimer. In addition, the dynamic modes are affected to various degrees by Sba1, a co-chaperone of Hsp90, depending on the location within Hsp90, which is in very good agreement with MD simulations. Altogether, this data is best described by fast molecule-spanning dynamics, which precede larger conformational changes in Hsp90 and might be the molecular basis for allostery. This integrative approach provides comprehensive insights into molecule-spanning dynamics on the nanosecond time scale for a multi-domain protein.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- heat shock protein 90
- molecular dynamics simulations
- neutron scattering
- protein dynamics
- single molecule fluorescence
- heat shock protein 90
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Till lärosätets databas
- Av författaren/redakt...
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Sohmen, Benedikt
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Beck, Christian
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Frank, Veronika
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Seydel, Tilo
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Hoffmann, Ingo
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Hermann, Bianca
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visa fler...
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Nüesch, Mark
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Grimaldo, Marco
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Schreiber, Frank
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Wolf, Steffen
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Roosen-Runge, Fe ...
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Hugel, Thorsten
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biofysik
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Fysikalisk kemi
- Artiklar i publikationen
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Advanced Science
- Av lärosätet
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Lunds universitet
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Malmö universitet