SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Pardo Julian)
 

Search: WFRF:(Pardo Julian) > Identification of F...

Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality

Albert, Marie Christine (author)
University of Cologne,University Hospital of Cologne
Uranga-Murillo, Iratxe (author)
Instituto de Investigación Sanitaria Aragón (IISA),University of Zaragoza
Arias, Maykel (author)
University of Zaragoza,Instituto de Investigación Sanitaria Aragón (IISA)
show more...
De Miguel, Diego (author)
Instituto de Investigación Sanitaria Aragón (IISA)
Peña, Natacha (author)
Instituto de Investigación Sanitaria Aragón (IISA)
Montinaro, Antonella (author)
UCL Cancer Institute
Varanda, Ana Beatriz (author)
University Hospital of Cologne,University of Cologne
Theobald, Sebastian J. (author)
University Hospital of Cologne
Areso, Itziar (author)
UCL Cancer Institute
Saggau, Julia (author)
University Hospital of Cologne,University of Cologne
Koch, Manuel (author)
University Hospital of Cologne
Liccardi, Gianmaria (author)
University of Cologne,University Hospital of Cologne
Peltzer, Nieves (author)
University Hospital of Cologne,University of Cologne
Rybniker, Jan (author)
University Hospital of Cologne
Hurtado-Guerrero, Ramón (author)
Aragonese Agency for Research and Development Researcher (ARAID),University of Copenhagen,University of Zaragoza
Merino, Pedro (author)
University of Zaragoza
Monzón, Marta (author)
University of Zaragoza
Badiola, Juan J. (author)
University of Zaragoza
Reindl-Schwaighofer, Roman (author)
Medical University of Vienna
Sanz-Pamplona, Rebeca (author)
Aragonese Agency for Research and Development Researcher (ARAID),CIBER Epidemiology and Public Health (CIBERESP),Instituto de Investigación Sanitaria Aragón (IISA)
Cebollada-Solanas, Alberto (author)
Aragon Health Sciences Institute
Megyesfalvi, Zsolt (author)
Medical University of Vienna,National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
Dome, Balazs (author)
Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University,Medical University of Vienna
Secrier, Maria (author)
University College London
Hartmann, Boris (author)
Bergmann, Michael (author)
Medical University of Vienna
Pardo, Julián (author)
Instituto de Investigación Sanitaria Aragón (IISA),University of Zaragoza
Walczak, Henning (author)
UCL Cancer Institute,University of Cologne
show less...
 (creator_code:org_t)
2024
2024
English 14 s.
In: Cell Death and Differentiation. - 1350-9047. ; 31:5, s. 544-557
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a novel mouse-adapted SARS-CoV-2 model (MA20) that recapitulates key pathological features of COVID-19. Concomitantly with occurrence of cell death and inflammation, FasL expression was significantly increased on inflammatory monocytic macrophages and NK cells in the lungs of MA20-infected mice. Importantly, therapeutic FasL inhibition markedly increased survival of both, young and old MA20-infected mice coincident with substantially reduced cell death and inflammation in their lungs. Intriguingly, FasL was also increased in the bronchoalveolar lavage fluid of critically-ill COVID-19 patients. Together, these results identify FasL as a crucial host factor driving the immuno-pathology that underlies COVID-19 severity and lethality, and imply that patients with severe COVID-19 may significantly benefit from therapeutic inhibition of FasL.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view