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Identification of F...
Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality
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- Albert, Marie Christine (author)
- University of Cologne,University Hospital of Cologne
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- Uranga-Murillo, Iratxe (author)
- Instituto de Investigación Sanitaria Aragón (IISA),University of Zaragoza
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- Arias, Maykel (author)
- University of Zaragoza,Instituto de Investigación Sanitaria Aragón (IISA)
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- De Miguel, Diego (author)
- Instituto de Investigación Sanitaria Aragón (IISA)
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- Peña, Natacha (author)
- Instituto de Investigación Sanitaria Aragón (IISA)
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- Montinaro, Antonella (author)
- UCL Cancer Institute
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- Varanda, Ana Beatriz (author)
- University Hospital of Cologne,University of Cologne
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- Theobald, Sebastian J. (author)
- University Hospital of Cologne
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- Areso, Itziar (author)
- UCL Cancer Institute
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- Saggau, Julia (author)
- University Hospital of Cologne,University of Cologne
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- Koch, Manuel (author)
- University Hospital of Cologne
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- Liccardi, Gianmaria (author)
- University of Cologne,University Hospital of Cologne
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- Peltzer, Nieves (author)
- University Hospital of Cologne,University of Cologne
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- Rybniker, Jan (author)
- University Hospital of Cologne
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- Hurtado-Guerrero, Ramón (author)
- Aragonese Agency for Research and Development Researcher (ARAID),University of Copenhagen,University of Zaragoza
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- Merino, Pedro (author)
- University of Zaragoza
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- Monzón, Marta (author)
- University of Zaragoza
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- Badiola, Juan J. (author)
- University of Zaragoza
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- Reindl-Schwaighofer, Roman (author)
- Medical University of Vienna
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- Sanz-Pamplona, Rebeca (author)
- Aragonese Agency for Research and Development Researcher (ARAID),CIBER Epidemiology and Public Health (CIBERESP),Instituto de Investigación Sanitaria Aragón (IISA)
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- Cebollada-Solanas, Alberto (author)
- Aragon Health Sciences Institute
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- Megyesfalvi, Zsolt (author)
- Medical University of Vienna,National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Dome, Balazs (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University,Medical University of Vienna
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- Secrier, Maria (author)
- University College London
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Hartmann, Boris (author)
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- Bergmann, Michael (author)
- Medical University of Vienna
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- Pardo, Julián (author)
- Instituto de Investigación Sanitaria Aragón (IISA),University of Zaragoza
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- Walczak, Henning (author)
- UCL Cancer Institute,University of Cologne
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(creator_code:org_t)
- 2024
- 2024
- English 14 s.
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In: Cell Death and Differentiation. - 1350-9047. ; 31:5, s. 544-557
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a novel mouse-adapted SARS-CoV-2 model (MA20) that recapitulates key pathological features of COVID-19. Concomitantly with occurrence of cell death and inflammation, FasL expression was significantly increased on inflammatory monocytic macrophages and NK cells in the lungs of MA20-infected mice. Importantly, therapeutic FasL inhibition markedly increased survival of both, young and old MA20-infected mice coincident with substantially reduced cell death and inflammation in their lungs. Intriguingly, FasL was also increased in the bronchoalveolar lavage fluid of critically-ill COVID-19 patients. Together, these results identify FasL as a crucial host factor driving the immuno-pathology that underlies COVID-19 severity and lethality, and imply that patients with severe COVID-19 may significantly benefit from therapeutic inhibition of FasL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Albert, Marie Ch ...
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Uranga-Murillo, ...
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Arias, Maykel
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De Miguel, Diego
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Peña, Natacha
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Montinaro, Anton ...
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show more...
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Varanda, Ana Bea ...
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Theobald, Sebast ...
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Areso, Itziar
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Saggau, Julia
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Koch, Manuel
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Liccardi, Gianma ...
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Peltzer, Nieves
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Rybniker, Jan
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Hurtado-Guerrero ...
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Merino, Pedro
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Monzón, Marta
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Badiola, Juan J.
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Reindl-Schwaigho ...
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Sanz-Pamplona, R ...
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Cebollada-Solana ...
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Megyesfalvi, Zso ...
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Dome, Balazs
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Secrier, Maria
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Hartmann, Boris
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Bergmann, Michae ...
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Pardo, Julián
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Walczak, Henning
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Cell Death and D ...
- By the university
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Lund University