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  • Gong, ZeNorthwestern Polytechnic University (författare)

The Association Between Quadriceps Strength and Synovitis in Knee Osteoarthritis : An Exploratory Study From the Osteoarthritis Initiative

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2022-12-15
  • The Journal of Rheumatology,2023
  • 8 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:222adf89-dce3-4ac4-b319-81c70c829912
  • https://lup.lub.lu.se/record/222adf89-dce3-4ac4-b319-81c70c829912URI
  • https://doi.org/10.3899/jrheum.220538DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • OBJECTIVE: The aim of this study was to explore the association between quadriceps strength and synovitis in knee osteoarthritis (KOA). METHODS: This study was derived from the Osteoarthritis Initiative (OAI), which recruited adults from the OAI cohort with or at risk of KOA. Knees with complete records of isometric quadriceps strength and effusion-synovitis and Hoffa-synovitis assessments were included. Quadriceps strength was measured isometrically at baseline. Effusion-synovitis and Hoffa-synovitis were measured using the Magnetic Resonance Imaging Osteoarthritis Knee Score at baseline and at 1-year and 2-year follow-ups. Generalized estimating equations were used to analyze the associations of baseline quadriceps strength with changes in effusion-synovitis and Hoffa-synovitis in multivariable analyses. Additionally, analyses were stratified by synovitis-driven inflammatory phenotypes. RESULTS: A total of 1513 knees were included in this study. In total, 61% of the subjects were female; subjects had an average age of 61.9 (SD 8.8) years and a mean BMI of 29.4 (SD 4.7). Regarding the whole population, baseline quadriceps strength was negatively associated with baseline effusion-synovitis and follow-up changes in effusion-synovitis (odds ratio [OR] 0.77-0.86), but no significant association was observed in terms of Hoffa-synovitis. Stratified by synovitis-driven inflammatory phenotype, baseline quadriceps strength was significantly associated with follow-up changes in effusion-synovitis-but not in Hoffa-synovitis-in the population with existing effusion-synovitis (OR 0.75-0.79). CONCLUSION: Higher baseline quadriceps strength was negatively associated with changes in effusion-synovitis-but not in Hoffa-synovitis-especially in the population with existing effusion-synovitis. Our findings suggested a potential protective role of the quadriceps in effusion-synovitis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Li, ShengfaSouthern Medical University (författare)
  • Cao, PeihuaSouthern Medical University (författare)
  • Ruan, GuangfengSouthern Medical University (författare)
  • Zhang, YanSouthern Medical University (författare)
  • Zeng, QingSouthern Medical University (författare)
  • He, ZijunSouthern Medical University (författare)
  • Li, ShilinSouthern Medical University (författare)
  • Chen, RongSouthern Medical University (författare)
  • Zheng, PengSouthern Medical University (författare)
  • Fan, TaoSouthern Medical University (författare)
  • Lu, PengchengSouthern Medical University (författare)
  • Zhao, YijinSouthern Medical University (författare)
  • Englund, MartinLund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)ort-med (författare)
  • Madry, HenningSaarland University Hospital (författare)
  • Huang, GuozhiSouthern Medical University (författare)
  • Li, LeNorthwestern Polytechnic University (författare)
  • Li, JiaSouthern Medical University (författare)
  • Ding, ChanghaiSouthern Medical University (författare)
  • Northwestern Polytechnic UniversitySouthern Medical University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The Journal of rheumatology: The Journal of Rheumatology50:4, s. 548-5550315-162X1499-2752

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