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Association of chan...
Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study
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- de las Heras Gala, Tonia (författare)
- German Center for Diabetes Research,Helmholtz Zentrum München
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- Herder, Christian (författare)
- German Center for Diabetes Research,Heinrich Heine University Düsseldorf
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- Rutters, Femke (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Carstensen-Kirberg, Maren (författare)
- Heinrich Heine University Düsseldorf,German Center for Diabetes Research
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- Huth, Cornelia (författare)
- German Center for Diabetes Research,Helmholtz Zentrum München
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- Stehouwer, Coen D.A. (författare)
- Maastricht University Medical Centre
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- Nijpels, Giel (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Schalkwijk, Casper (författare)
- Maastricht University Medical Centre
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- Flyvbjerg, Allan (författare)
- Steno Diabetes Center Copenhagen
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Dekker, Jacqueline (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Meisinger, Christa (författare)
- Ludwig-Maximilian University of Munich,Helmholtz Zentrum München,German Center for Diabetes Research
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- Koenig, Wolfgang (författare)
- University of Ulm,Technical University of Munich,German Centre for Cardiovascular Research
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- Roden, Michael (författare)
- German Center for Diabetes Research,Heinrich Heine University Düsseldorf
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- Rathmann, Wolfgang (författare)
- German Center for Diabetes Research,Heinrich Heine University Düsseldorf
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- Peters, Annette (författare)
- German Center for Diabetes Research,German Centre for Cardiovascular Research,Helmholtz Zentrum München
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- Thorand, Barbara (författare)
- Helmholtz Zentrum München,German Center for Diabetes Research
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(creator_code:org_t)
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- 2018-10-02
- 2018
- Engelska.
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Ingår i: Diabetes/Metabolism Research and Reviews. - : Wiley. - 1520-7552. ; 34:8
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA1c, HOMA-IR, and HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations. Materials and methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model. Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c. All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates. Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- glycaemic deterioration
- HbA
- inflammation
- insulin resistance
- ß-cell function
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- ref (ämneskategori)
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de las Heras Gal ...
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Herder, Christia ...
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Rutters, Femke
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Carstensen-Kirbe ...
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Huth, Cornelia
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Stehouwer, Coen ...
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Nijpels, Giel
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Schalkwijk, Casp ...
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Flyvbjerg, Allan
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Franks, Paul W.
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Dekker, Jacqueli ...
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Meisinger, Chris ...
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Koenig, Wolfgang
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Roden, Michael
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Rathmann, Wolfga ...
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Peters, Annette
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Thorand, Barbara
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