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Cerebrovascular Eve...
Cerebrovascular Events in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study
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- Hanly, John G. (författare)
- Dalhousie University
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- Li, Qiuju (författare)
- University of Cambridge
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- Su, Li (författare)
- University of Cambridge
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- Urowitz, Murray B. (författare)
- University of Toronto
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- Gordon, Caroline (författare)
- University of Birmingham
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- Bae, Sang Cheol (författare)
- Hanyang University
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- Romero-Diaz, Juanita (författare)
- Instituto Nacional de Ciencias Médicas y Nutrición
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- Sanchez-Guerrero, Jorge (författare)
- University of Toronto,Toronto Western Hospital
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- Bernatsky, Sasha (författare)
- McGill University
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- Clarke, Ann E. (författare)
- University of Calgary
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- Wallace, Daniel J. (författare)
- Cedars-Sinai Medical Center,University of California, Los Angeles
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- Isenberg, David A. (författare)
- University College London,New York University
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- Rahman, Anisur (författare)
- University College London
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- Merrill, Joan T. (författare)
- Oklahoma Medical Research Foundation
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- Fortin, Paul (författare)
- Centre hospitalier universitaire de Québec
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- Gladman, Dafna D. (författare)
- University of Toronto,Toronto Western Hospital
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- Bruce, Ian N. (författare)
- Manchester University NHS Foundation Trust,University of Manchester
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- Petri, Michelle (författare)
- Johns Hopkins University
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- Ginzler, Ellen M. (författare)
- SUNY Downstate Health Sciences University,Feinstein Institute for Medical Research
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- Dooley, M. A. (författare)
- University of North Carolina
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- Steinsson, Kristjan (författare)
- National University Hospital of Iceland
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- Ramsey-Goldman, Rosalind (författare)
- Northwestern University
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- Zoma, Asad A. (författare)
- Hairmyres Hospital
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- Manzi, Susan (författare)
- Allegheny Health Network
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- Nived, Ola (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jonsen, Andreas (författare)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Khamashta, Munther A. (författare)
- King's College London,St Thomas' Hospital
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- Alarcón, Graciela S. (författare)
- University of Alabama
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- Chatham, Winn (författare)
- University of Alabama
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- van Vollenhoven, Ronald F. (författare)
- Karolinska Institutet,Karolinska Institute
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- Aranow, Cynthia (författare)
- Feinstein Institute for Medical Research
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- Mackay, Meggan (författare)
- Feinstein Institute for Medical Research
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- Ruiz-Irastorza, Guillermo (författare)
- Gurutzeta/Cruces University Hospital,University of the Basque Country
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- Ramos-Casals, Manuel (författare)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona
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- Lim, S. Sam (författare)
- Emory University
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- Inanc, Murat (författare)
- Istanbul University
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- Kalunian, Kenneth C. (författare)
- University of California, San Diego
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- Jacobsen, Soren (författare)
- Copenhagen University Hospital
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- Peschken, Christine A. (författare)
- University of Manitoba
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- Kamen, Diane L. (författare)
- Medical University of South Carolina
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- Askanase, Anca (författare)
- New York University
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- Theriault, Chris (författare)
- Dalhousie University
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- Farewell, Vernon (författare)
- University of Cambridge
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(creator_code:org_t)
- 2018-09-01
- 2018
- Engelska 10 s.
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Ingår i: Arthritis Care and Research. - : Wiley. - 2151-464X .- 2151-4658. ; 70:10, s. 1478-1487
- Relaterad länk:
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http://dx.doi.org/10...
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https://discovery.uc...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient ischemia, 3) chronic multifocal ischemia, 4) subarachnoid/intracranial hemorrhage, and 5) sinus thrombosis. Global disease activity (Systemic Lupus Erythematosus Disease [SLE] Activity Index 2000), damage scores (SLE International Collaborating Clinics/American College of Rheumatology Damage Index), and Short Form 36 (SF-36) scores were collected. Time to event, linear and logistic regressions, and multistate models were used as appropriate. Results: CerVEs were the fourth most frequent NP event: 82 of 1,826 patients had 109 events; of these events, 103 were attributed to SLE, and 44 were identified at the time of enrollment. The predominant events were stroke (60 of 109 patients) and transient ischemia (28 of 109 patients). CerVEs were associated with other NP events attributed to SLE, non–SLE-attributed NP events, African ancestry (at US SLICC sites), and increased organ damage scores. Lupus anticoagulant increased the risk of first stroke and sinus thrombosis and transient ischemic attack. Physician assessment indicated resolution or improvement in the majority of patients, but patients reported sustained reduction in SF-36 summary and subscale scores following a CerVE. Conclusion: CerVEs, the fourth most frequent NP event in SLE, are usually attributable to lupus. In contrast to good physician-reported outcomes, patients reported a sustained reduction in health-related quality of life following a CerVE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hanly, John G.
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Li, Qiuju
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Su, Li
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Urowitz, Murray ...
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Gordon, Caroline
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Bae, Sang Cheol
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visa fler...
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Bernatsky, Sasha
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Clarke, Ann E.
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Fortin, Paul
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Gladman, Dafna D ...
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Bruce, Ian N.
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Petri, Michelle
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Ginzler, Ellen M ...
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Dooley, M. A.
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Steinsson, Krist ...
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Ramsey-Goldman, ...
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Zoma, Asad A.
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Manzi, Susan
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Nived, Ola
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Jonsen, Andreas
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Khamashta, Munth ...
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Alarcón, Graciel ...
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Chatham, Winn
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van Vollenhoven, ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Ramos-Casals, Ma ...
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Lim, S. Sam
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Inanc, Murat
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Kalunian, Kennet ...
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Jacobsen, Soren
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Peschken, Christ ...
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Kamen, Diane L.
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Askanase, Anca
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Theriault, Chris
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Farewell, Vernon
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Lunds universitet
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Karolinska Institutet