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  • Maguire, Jane M.Hunter Medical Research Institute, Australia,University of Newcastle,University of Technology Sydney (author)

GISCOME – Genetics of Ischaemic Stroke Functional Outcome network : A protocol for an international multicentre genetic association study

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-04-19
  • SAGE Publications,2017
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:2394e9d1-4fe2-4fef-b61a-b5502f5ac9d6
  • https://lup.lub.lu.se/record/2394e9d1-4fe2-4fef-b61a-b5502f5ac9d6URI
  • https://doi.org/10.1177/2396987317704547DOI
  • https://gup.ub.gu.se/publication/266340URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Introduction: Genome-wide association studies have identified several novel genetic loci associated with stroke risk, but how genetic factors influence stroke outcome is less studied. The Genetics of Ischaemic Stroke Functional outcome network aims at performing genetic studies of stroke outcome. We here describe the study protocol and methods basis of Genetics of Ischaemic Stroke Functional outcome. Methods: The Genetics of Ischaemic Stroke Functional outcome network has assembled patients from 12 ischaemic stroke projects with genome-wide genotypic and outcome data from the International Stroke Genetics Consortium and the National Institute of Neurological Diseases Stroke Genetics Network initiatives. We have assessed the availability of baseline variables, outcome metrics and time-points for collection of outcome data. Results: We have collected 8831 ischaemic stroke cases with genotypic and outcome data. Modified Rankin score was the outcome metric most readily available. We detected heterogeneity between cohorts for age and initial stroke severity (according to the NIH Stroke Scale), and will take this into account in analyses. We intend to conduct a first phase genome-wide association outcome study on ischaemic stroke cases with data on initial stroke severity and modified Rankin score within 60–190 days. To date, we have assembled 5762 such cases and are currently seeking additional cases meeting these criteria for second phase analyses. Conclusion: Genetics of Ischaemic Stroke Functional outcome is a unique collection of ischaemic stroke cases with detailed genetic and outcome data providing an opportunity for discovery of genetic loci influencing functional outcome. Genetics of Ischaemic Stroke Functional outcome will serve as an exploratory study where the results as well as the methodological observations will provide a basis for future studies on functional outcome. Genetics of Ischaemic Stroke Functional outcome can also be used for candidate gene replication or assessing stroke outcome non-genetic association hypotheses.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bevan, SteveUniversity of Lincoln (author)
  • Stanne, Tara M.Sahlgrenska Academy (author)
  • Lorenzen, ErikSahlgrenska Academy (author)
  • Fernandez-Cadenas, IsraelMutua De Terrassa Hospital,Vall d'Hebron University Hospital (author)
  • Hankey, Graeme J.University of Western Australia, Crawley (author)
  • Jimenez-Conde, JordiHospital del Mar Medical Research Institute (author)
  • Jood, Katarina,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xjooka (author)
  • Lee, Jin MooWashington University in St. Louis (author)
  • Lemmens, RobinFlanders Interuniversity Institute for Biotechnology,Catholic University of Leuven,University Hospitals Leuven (author)
  • Levi, ChristopherHunter Medical Research Institute, Australia,University of Newcastle (author)
  • Norrving, BoLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)neur-bno (author)
  • Rannikmae, KristiinaUniversity of Edinburgh (author)
  • Rost, NataliaMassachusetts General Hospital (author)
  • Rosand, JonathanBroad Institute,Massachusetts General Hospital (author)
  • Rothwell, Peter M.University of Oxford (author)
  • Scott, RodneyUniversity of Technology Sydney,Hunter Medical Research Institute, Australia (author)
  • Strbian, DanielHelsinki University Central Hospital (author)
  • Sturm, JonathanUniversity of Newcastle (author)
  • Sudlow, CathieUniversity of Edinburgh (author)
  • Traylor, MatthewUniversity of Cambridge (author)
  • Thijs, VincentUniversity of Melbourne,Austin Health (author)
  • Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt (author)
  • Wieloch, TadeuszLund University,Lunds universitet,Laboratory for Experimental Brain Research,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)efor-twi (author)
  • Woo, DanielUniversity of Cincinnati (author)
  • Worrall, Bradford B.University of Virginia (author)
  • Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xjerch (author)
  • Lindgren, ArneLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)neur-ali (author)
  • Hunter Medical Research Institute, AustraliaUniversity of Newcastle (creator_code:org_t)

Related titles

  • In:European Stroke Journal: SAGE Publications2:3, s. 229-2372396-98732396-9881

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