Search: (WFRF:(Pirmoradian Mohammad)) >
Proteogenomics of n...
Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms
-
- Lehtiö, Janne (author)
- Karolinska Institutet,Karolinska Institute
-
- Arslan, Taner (author)
- Karolinska Institute
-
- Siavelis, Ioannis (author)
- Karolinska Institutet,Karolinska Institute
-
show more...
-
- Pan, Yanbo (author)
- Karolinska Institutet,Karolinska Institute
-
- Socciarelli, Fabio (author)
- Karolinska Institute
-
- Berkovska, Olena (author)
- Karolinska Institutet,Karolinska Institute
-
- Umer, Husen M. (author)
- Karolinska Institutet,Karolinska Institute
-
- Mermelekas, Georgios (author)
- Karolinska Institute
-
- Pirmoradian, Mohammad (author)
- Karolinska Institute
-
- Jönsson, Mats (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Brunnström, Hans (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne
-
- Brustugun, Odd Terje (author)
- Vestre Viken Health Trust,Oslo university hospital
-
- Purohit, Krishna Pinganksha (author)
- University of Edinburgh
-
- Cunningham, Richard (author)
- University of Edinburgh
-
- Foroughi Asl, Hassan (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
-
- Isaksson, Sofi (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Arbajian, Elsa (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Aine, Mattias (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Karlsson, Anna (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Kotevska, Marija (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
-
- Gram Hansen, Carsten (author)
- University of Edinburgh
-
- Drageset Haakensen, Vilde (author)
- Oslo university hospital
-
- Helland, Åslaug (author)
- Oslo university hospital,University of Oslo
-
- Tamborero, David (author)
- Karolinska Institutet,Karolinska Institute
-
- Johansson, Henrik J. (author)
- Karolinska Institutet,Karolinska Institute
-
- Branca, Rui M. (author)
- Karolinska Institutet,Karolinska Institute
-
- Planck, Maria (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
-
- Staaf, Johan (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Orre, Lukas M. (author)
- Karolinska Institutet,Karolinska Institute
-
show less...
-
(creator_code:org_t)
- 2021-11-22
- 2021
- English 19 s.
-
In: Nature Cancer. - : Springer Science and Business Media LLC. - 2662-1347. ; 2:11, s. 1224-1242
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Despite major advancements in lung cancer treatment, long-term survival is still rare and a deeper understanding of molecular phenotypes would allow the identification of specific cancer dependencies and immune-evasion mechanisms. Here we performed in-depth mass-spectrometry-based proteogenomic analysis of 141 tumors representing all major histologies of non-small cell lung cancer (NSCLC). We identified six distinct proteome subtypes with striking differences in immune cell composition and subtype-specific expression of immune checkpoints. Unexpectedly, high neoantigen burden was linked to global hypomethylation and complex neoantigens mapped to genomic regions, such as endogenous retroviral elements and introns, in immune-cold subtypes. Further, we linked immune evasion with LAG-3 via STK11 mutation-dependent HNF1A activation and FGL1 expression. Finally, we develop a data-independent acquisition mass-spectrometry-based NSCLC subtype classification method, validate it in an independent cohort of 208 NSCLC cases and demonstrate its clinical utility by analyzing an additional cohort of 84 late-stage NSCLC biopsy samples.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lehtiö, Janne
-
Arslan, Taner
-
Siavelis, Ioanni ...
-
Pan, Yanbo
-
Socciarelli, Fab ...
-
Berkovska, Olena
-
show more...
-
Umer, Husen M.
-
Mermelekas, Geor ...
-
Pirmoradian, Moh ...
-
Jönsson, Mats
-
Brunnström, Hans
-
Brustugun, Odd T ...
-
Purohit, Krishna ...
-
Cunningham, Rich ...
-
Foroughi Asl, Ha ...
-
Isaksson, Sofi
-
Arbajian, Elsa
-
Aine, Mattias
-
Karlsson, Anna
-
Kotevska, Marija
-
Gram Hansen, Car ...
-
Drageset Haakens ...
-
Helland, Åslaug
-
Tamborero, David
-
Johansson, Henri ...
-
Branca, Rui M.
-
Planck, Maria
-
Staaf, Johan
-
Orre, Lukas M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Nature Cancer
- By the university
-
Lund University
-
Karolinska Institutet