Search: ((WFRF:(Chan Emily)) srt2:(2015-2019))
> (2015) >
Antagonistic Human ...
Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo.
-
Roghanian, Ali (author)
-
- Teige, Ingrid (author)
- BioInvent International AB
-
- Mårtensson, Linda (author)
- BioInvent International AB
-
show more...
-
Cox, Kerry L (author)
-
- Kovacek, Mathilda (author)
- BioInvent International AB
-
Ljungars, Anne (author)
-
- Mattson, Jenny (author)
- BioInvent International AB
-
Sundberg, Annika (author)
-
Vaughan, Andrew T (author)
-
Shah, Vallari (author)
-
Smyth, Neil R (author)
-
Sheth, Bhavwanti (author)
-
Chan, H T Claude (author)
-
Li, Zhan-Chun (author)
-
Williams, Emily L (author)
-
Manfredi, Giusi (author)
-
Oldham, Robert J (author)
-
Mockridge, C Ian (author)
-
James, Sonya A (author)
-
Dahal, Lekh N (author)
-
Hussain, Khiyam (author)
-
- Nilsson, Björn (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
Verbeek, J Sjef (author)
-
- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Skåne University Hospital
-
- Hansson, Markus (author)
- Lund University,Lunds universitet,Skåne University Hospital
-
- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Skåne University Hospital
-
Johnson, Peter W M (author)
-
Davies, Andrew (author)
-
Beers, Stephen A (author)
-
Glennie, Martin J (author)
-
Frendéus, Björn (author)
-
Cragg, Mark S (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
-
In: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 27:4, s. 473-488
- Related links:
-
http://www.ncbi.nlm....
-
show more...
-
http://dx.doi.org/10...
-
http://www.cell.com/...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Therapeutic antibodies have transformed cancer therapy, unlocking mechanisms of action by engaging the immune system. Unfortunately, cures rarely occur and patients display intrinsic or acquired resistance. Here, we demonstrate the therapeutic potential of targeting human (h) FcγRIIB (CD32B), a receptor implicated in immune cell desensitization and tumor cell resistance. FcγRIIB-blocking antibodies prevented internalization of the CD20-specific antibody rituximab, thereby maximizing cell surface accessibility and immune effector cell mediated antitumor activity. In hFcγRIIB-transgenic (Tg) mice, FcγRIIB-blocking antibodies effectively deleted target cells in combination with rituximab, and other therapeutic antibodies, from resistance-prone stromal compartments. Similar efficacy was seen in primary human tumor xenografts, including with cells from patients with relapsed/refractory disease. These data support the further development of hFcγRIIB antibodies for clinical assessment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Roghanian, Ali
-
Teige, Ingrid
-
Mårtensson, Lind ...
-
Cox, Kerry L
-
Kovacek, Mathild ...
-
Ljungars, Anne
-
show more...
-
Mattson, Jenny
-
Sundberg, Annika
-
Vaughan, Andrew ...
-
Shah, Vallari
-
Smyth, Neil R
-
Sheth, Bhavwanti
-
Chan, H T Claude
-
Li, Zhan-Chun
-
Williams, Emily ...
-
Manfredi, Giusi
-
Oldham, Robert J
-
Mockridge, C Ian
-
James, Sonya A
-
Dahal, Lekh N
-
Hussain, Khiyam
-
Nilsson, Björn
-
Verbeek, J Sjef
-
Juliusson, Gunna ...
-
Hansson, Markus
-
Jerkeman, Mats
-
Johnson, Peter W ...
-
Davies, Andrew
-
Beers, Stephen A
-
Glennie, Martin ...
-
Frendéus, Björn
-
Cragg, Mark S
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancer Cell
- By the university
-
Lund University