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  • Roghanian, Ali (author)

Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo.

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Elsevier BV,2015

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:23ee3f4d-5345-4d96-b34e-6c21ef067e22
  • https://lup.lub.lu.se/record/5341867URI
  • https://doi.org/10.1016/j.ccell.2015.03.005DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Therapeutic antibodies have transformed cancer therapy, unlocking mechanisms of action by engaging the immune system. Unfortunately, cures rarely occur and patients display intrinsic or acquired resistance. Here, we demonstrate the therapeutic potential of targeting human (h) FcγRIIB (CD32B), a receptor implicated in immune cell desensitization and tumor cell resistance. FcγRIIB-blocking antibodies prevented internalization of the CD20-specific antibody rituximab, thereby maximizing cell surface accessibility and immune effector cell mediated antitumor activity. In hFcγRIIB-transgenic (Tg) mice, FcγRIIB-blocking antibodies effectively deleted target cells in combination with rituximab, and other therapeutic antibodies, from resistance-prone stromal compartments. Similar efficacy was seen in primary human tumor xenografts, including with cells from patients with relapsed/refractory disease. These data support the further development of hFcγRIIB antibodies for clinical assessment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Teige, IngridBioInvent International AB(Swepub:lu)infl-ite (author)
  • Mårtensson, LindaBioInvent International AB(Swepub:lu)onk-lma (author)
  • Cox, Kerry L (author)
  • Kovacek, MathildaBioInvent International AB(Swepub:lu)klke-mko (author)
  • Ljungars, Anne (author)
  • Mattson, JennyBioInvent International AB(Swepub:lu)je3265ma (author)
  • Sundberg, Annika (author)
  • Vaughan, Andrew T (author)
  • Shah, Vallari (author)
  • Smyth, Neil R (author)
  • Sheth, Bhavwanti (author)
  • Chan, H T Claude (author)
  • Li, Zhan-Chun (author)
  • Williams, Emily L (author)
  • Manfredi, Giusi (author)
  • Oldham, Robert J (author)
  • Mockridge, C Ian (author)
  • James, Sonya A (author)
  • Dahal, Lekh N (author)
  • Hussain, Khiyam (author)
  • Nilsson, BjörnLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klin-bni (author)
  • Verbeek, J Sjef (author)
  • Juliusson, GunnarLund University,Lunds universitet,Skåne University Hospital(Swepub:lu)stem-gju (author)
  • Hansson, MarkusLund University,Lunds universitet,Skåne University Hospital(Swepub:lu)hema-mha (author)
  • Jerkeman, MatsLund University,Lunds universitet,Skåne University Hospital(Swepub:lu)onk-mje (author)
  • Johnson, Peter W M (author)
  • Davies, Andrew (author)
  • Beers, Stephen A (author)
  • Glennie, Martin J (author)
  • Frendéus, Björn (author)
  • Cragg, Mark S (author)
  • BioInvent International ABAvdelningen för hematologi och transfusionsmedicin (creator_code:org_t)

Related titles

  • In:Cancer Cell: Elsevier BV27:4, s. 473-4881878-36861535-6108

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