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Phylogeographic Ass...
Phylogeographic Assessment Reveals Geographic Sources of HIV-1 Dissemination Among Men Who Have Sex With Men in Kenya
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- Nduva, George M. (författare)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)
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Otieno, Frederick (författare)
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- Kimani, Joshua (författare)
- University of Manitoba
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- McKinnon, Lyle R. (författare)
- University of Manitoba
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- Cholette, Francois (författare)
- University of Manitoba
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Sandstrom, Paul (författare)
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- Graham, Susan M. (författare)
- University of Washington,Kenya Medical Research Institute (KEMRI)
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- Price, Matt A. (författare)
- University of California, San Francisco
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- Smith, Adrian D. (författare)
- University of Oxford
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- Bailey, Robert C. (författare)
- University of Illinois at Chicago
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- Hassan, Amin S. (författare)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)
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- Esbjörnsson, Joakim (författare)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
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- Sanders, Eduard J. (författare)
- University of Oxford
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(creator_code:org_t)
- 2022-03-09
- 2022
- Engelska.
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Ingår i: Frontiers in Microbiology. - : Frontiers Media SA. - 1664-302X. ; 13
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- HIV-1 transmission dynamics involving men who have sex with men (MSM) in Africa are not well understood. We investigated the rates of HIV-1 transmission between MSM across three regions in Kenya: Coast, Nairobi, and Nyanza. We analyzed 372 HIV-1 partial pol sequences sampled during 2006–2019 from MSM in Coast (N = 178, 47.9%), Nairobi (N = 137, 36.8%), and Nyanza (N = 57, 15.3%) provinces in Kenya. Maximum-likelihood (ML) phylogenetics and Bayesian inference were used to determine HIV-1 clusters, evolutionary dynamics, and virus migration rates between geographic regions. HIV-1 sub-subtype A1 (72.0%) was most common followed by subtype D (11.0%), unique recombinant forms (8.9%), subtype C (5.9%), CRF 21A2D (0.8%), subtype G (0.8%), CRF 16A2D (0.3%), and subtype B (0.3%). Forty-six clusters (size range 2–20 sequences) were found—half (50.0%) of which had evidence of extensive HIV-1 mixing among different provinces. Data revealed an exponential increase in infections among MSM during the early-to-mid 2000s and stable or decreasing transmission dynamics in recent years (2017–2019). Phylogeographic inference showed significant (Bayes factor, BF > 3) HIV-1 dissemination from Coast to Nairobi and Nyanza provinces, and from Nairobi to Nyanza province. Strengthening HIV-1 prevention programs to MSM in geographic locations with higher HIV-1 prevalence among MSM (such as Coast and Nairobi) may reduce HIV-1 incidence among MSM in Kenya.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- HIV-1
- Kenya
- molecular epidemiology
- MSM
- phylogeographic
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- ref (ämneskategori)
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- Av författaren/redakt...
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Nduva, George M.
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Otieno, Frederic ...
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Kimani, Joshua
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McKinnon, Lyle R ...
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Cholette, Franco ...
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Sandstrom, Paul
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visa fler...
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Graham, Susan M.
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Price, Matt A.
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Smith, Adrian D.
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Bailey, Robert C ...
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Hassan, Amin S.
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Esbjörnsson, Joa ...
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Sanders, Eduard ...
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visa färre...
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