Search: WFRF:(Hassan Amin S)
> (2022) >
Quantifying rates o...
Quantifying rates of HIV-1 flow between risk groups and geographic locations in Kenya : A country-wide phylogenetic study
-
- Nduva, George M. (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)
-
- Otieno, Frederick (author)
- Nyanza Reproductive Health Society
-
- Kimani, Joshua (author)
- University of Nairobi,University of Manitoba
-
show more...
-
- Wahome, Elizabeth (author)
- Kenya Medical Research Institute (KEMRI)
-
- McKinnon, Lyle R. (author)
- University of Manitoba,University of Nairobi,University of KwaZulu-Natal
-
- Cholette, Francois (author)
- University of Manitoba
-
- Majiwa, Maxwell (author)
- Kenya Medical Research Institute (KEMRI)
-
- Masika, Moses (author)
- University of Nairobi
-
- Mutua, Gaudensia (author)
- University of Nairobi
-
- Anzala, Omu (author)
- University of Nairobi
-
- Graham, Susan M. (author)
- Kenya Medical Research Institute (KEMRI),University of Washington
-
- Gelmon, Larry (author)
- University of Nairobi,University of Manitoba
-
- Price, Matt A. (author)
- University of California, San Francisco
-
- Smith, Adrian D. (author)
- University of Oxford
-
- Bailey, Robert C. (author)
- Nyanza Reproductive Health Society,University of Illinois at Chicago
-
- Baele, Guy (author)
- Catholic University of Leuven
-
- Lemey, Philippe (author)
- Catholic University of Leuven
-
- Hassan, Amin S. (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)
-
- Sanders, Eduard J. (author)
- Kenya Medical Research Institute (KEMRI),University of Oxford
-
- Esbjörnsson, Joakim (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
-
show less...
-
(creator_code:org_t)
- 2022-03-03
- 2022
- English.
-
In: Virus Evolution. - : Oxford University Press (OUP). - 2057-1577. ; 8:1
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In Kenya, HIV-1 key populations including men having sex with men (MSM), people who inject drugs (PWID) and female sex workers (FSW) are thought to significantly contribute to HIV-1 transmission in the wider, mostly heterosexual (HET) HIV-1 transmission network. However, clear data on HIV-1 transmission dynamics within and between these groups are limited. We aimed to empirically quantify rates of HIV-1 flow between key populations and the HET population, as well as between different geographic regions to determine HIV-1 'hotspots' and their contribution to HIV-1 transmission in Kenya. We used maximum-likelihood phylogenetic and Bayesian inference to analyse 4058 HIV-1 pol sequences (representing 0.3 per cent of the epidemic in Kenya) sampled 1986-2019 from individuals of different risk groups and regions in Kenya. We found 89 per cent within-risk group transmission and 11 per cent mixing between risk groups, cyclic HIV-1 exchange between adjoining geographic provinces and strong evidence of HIV-1 dissemination from (i) West-to-East (i.e. higher-to-lower HIV-1 prevalence regions), and (ii) heterosexual-to-key populations. Low HIV-1 prevalence regions and key populations are sinks rather than major sources of HIV-1 transmission in Kenya. Targeting key populations in Kenya needs to occur concurrently with strengthening interventions in the general epidemic.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- HIV-1
- key populations
- molecular epidemiology
- transmission
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Nduva, George M.
-
Otieno, Frederic ...
-
Kimani, Joshua
-
Wahome, Elizabet ...
-
McKinnon, Lyle R ...
-
Cholette, Franco ...
-
show more...
-
Majiwa, Maxwell
-
Masika, Moses
-
Mutua, Gaudensia
-
Anzala, Omu
-
Graham, Susan M.
-
Gelmon, Larry
-
Price, Matt A.
-
Smith, Adrian D.
-
Bailey, Robert C ...
-
Baele, Guy
-
Lemey, Philippe
-
Hassan, Amin S.
-
Sanders, Eduard ...
-
Esbjörnsson, Joa ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
- Articles in the publication
-
Virus Evolution
- By the university
-
Lund University