Sökning: L773:2227 9059 >
A comparison betwee...
A comparison between endostatin and conventional biomarkers on 30-day mortality and renal replacement therapy in unselected intensive care patients
-
- Ruge, Toralph (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Department of Emergency and Internal Medicine, Skåne University Hospital, 214 28 Malmö, Sweden,Department of Emergency and Internal Medicine, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
-
- Larsson, Anders (författare)
- Uppsala universitet,Uppsala University,Klinisk kemi,Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
-
- Lipcsey, Miklós (författare)
- Uppsala universitet,Uppsala University,Anestesiologi och intensivvård,Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden
-
visa fler...
-
- Tydén, Jonas (författare)
- Umeå universitet,Umeå University,Department of Surgical and Perioperative Sciences, Anaesthesiology and Critical Care Medicine (Östersund), Umeå University, 901 87 Umeå, Sweden,Anestesiologi och intensivvård
-
- Johansson, Joakim (författare)
- Umeå universitet,Umeå University,Department of Surgical and Perioperative Sciences, Anaesthesiology and Critical Care Medicine (Östersund), Umeå University, 901 87 Umeå, Sweden,Anestesiologi och intensivvård
-
- Eriksson, Mats (författare)
- Uppsala universitet,Uppsala University,Anestesiologi och intensivvård,Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2021-11-03
- 2021
- Engelska.
-
Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 9:11
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://www.mdpi.com...
-
https://doi.org/10.3...
-
https://uu.diva-port... (primary) (Raw object)
-
https://umu.diva-por... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Endostatin may predict mortality and kidney impairment in general populations as well as in critically ill patients. We decided to explore the possible role of endostatin as a predictor of 30-day mortality, acute kidney injury (AKI), and renal replacement therapy (RRT) in a cohort of unselected intensive care unit (ICU) patients. Endostatin and creatinine in plasma were analyzed and SAPS3 was determined in 278 patients on ICU arrival at admission to a Swedish medium-sized hospital. SAPS3 had the highest predictive value, 0.85 (95% C.I.: 0.8–0.90), for 30-day mortality. Endostatin, in combination with age, predicted 30-day mortality by 0.76 (95% C.I.: 0.70–0.82). Endostatin, together with age and creatinine, predicted AKI with 0.87 (95% C.I.: 0.83–0.91). Endostatin predicted AKI with [0.68 (0.62–0.74)]. Endostatin predicted RRT, either alone [0.82 (95% C.I.: 0.72–0.91)] or together with age [0.81 (95% C.I.: 0.71–0.91)]. The predicted risk for 30-day mortality, AKI, or RRT during the ICU stay, predicted by plasma endostatin, was not influenced by age. Compared to the complex severity score SAPS3, circulating endostatin, combined with age, offers an easily managed option to predict 30-day mortality. Additionally, circulating endostatin combined with creatinine was closely associated with AKI development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Acute kidney injury
- Critical illness
- Endostatin
- Epidemiology
- Intensive care unit
- Mortality
- Renal replacement therapy
- SAPS3
- General Biochemistry
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas