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  • Georgakis, Marios K.University Hospital Munich,Ludwig-Maximilian University of Munich (author)

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke : Meta-Analysis of Population-Based Studies Involving 17 180 Individuals

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:2487f2ad-8be0-49c1-b3b2-9f1b72524992
  • https://lup.lub.lu.se/record/2487f2ad-8be0-49c1-b3b2-9f1b72524992URI
  • https://doi.org/10.1161/CIRCRESAHA.119.315380DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Rationale: Proinflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke. However, data from large-scale observational studies are lacking. Objective: To determine whether circulating levels of MCP-1 are associated with risk of incident stroke in the general population. Methods and Results: We used previously unpublished data on 17 180 stroke-free individuals (mean age, 56.7±8.1 years; 48.8% men) from 6 population-based prospective cohort studies and explored associations between baseline circulating MCP-1 levels and risk of any stroke, ischemic stroke, and hemorrhagic stroke during a mean follow-up interval of 16.3 years (280 522 person-years at risk; 1435 incident stroke events). We applied Cox proportional-hazards models and pooled hazard ratios (HRs) using random-effects meta-analyses. After adjustments for age, sex, race, and vascular risk factors, higher MCP-1 levels were associated with increased risk of any stroke (HR per 1-SD increment in ln-transformed MCP-1, 1.07; 95% CI, 1.01-1.14). Focusing on stroke subtypes, we found a significant association between baseline MCP-1 levels and higher risk of ischemic stroke (HR, 1.11 [1.02-1.21]) but not hemorrhagic stroke (HR, 1.02 [0.82-1.29]). The results followed a dose-response pattern with a higher risk of ischemic stroke among individuals in the upper quartiles of MCP-1 levels as compared with the first quartile (HRs, second quartile: 1.19 [1.00-1.42]; third quartile: 1.35 [1.14-1.59]; fourth quartile: 1.38 [1.07-1.77]). There was no indication for heterogeneity across studies, and in a subsample of 4 studies (12 516 individuals), the risk estimates were stable after additional adjustments for circulating levels of IL (interleukin)-6 and high-sensitivity CRP (C-reactive protein). Conclusions: Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1 signaling might represent a therapeutic target to lower stroke risk.Visual Overview: An online visual overview is available for this article.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Malik, RainerUniversity Hospital Munich,Ludwig-Maximilian University of Munich (author)
  • Björkbacka, HarryLund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups(Swepub:lu)medf-hbj (author)
  • Pana, Tiberiu AlexandruUniversity of Aberdeen (author)
  • Demissie, SerkalemFramingham Heart Study,Boston University (author)
  • Ayers, ColbyUniversity of Texas Southwestern Medical Center (author)
  • Elhadad, Mohamed A.German Centre for Cardiovascular Research,Helmholtz Zentrum München (author)
  • Fornage, MyriamUniversity of Texas Health Science Centre (author)
  • Beiser, Alexa S.Framingham Heart Study,Boston University (author)
  • Benjamin, Emelia J.Boston University,Framingham Heart Study (author)
  • Boekholdt, Matthijs S.Academic Medical Center of University of Amsterdam (AMC) (author)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
  • Herder, ChristianHeinrich Heine University Düsseldorf (author)
  • Hoogeveen, Ron C.Baylor College of Medicine (author)
  • Koenig, WolfgangUniversity of Ulm,German Centre for Cardiovascular Research,Technical University of Munich (author)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
  • Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (author)
  • Schiopu, AlexandruLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-asc (author)
  • Söderholm, MartinLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)med-ms8 (author)
  • Wareham, NickUniversity of Cambridge (author)
  • Ballantyne, Christie M.Baylor College of Medicine (author)
  • Peters, AnnetteHelmholtz Zentrum München (author)
  • Seshadri, SudhaBoston University,University of Texas Health Science Centre,Framingham Heart Study (author)
  • Myint, Phyo K.University of Aberdeen (author)
  • Nilsson, JanLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-jni (author)
  • de Lemos, James A.University of Texas Southwestern Medical Center (author)
  • Dichgans, MartinGerman Center for Neurodegenerative Diseases (DZNE), Bonn,Munich Cluster for Systems Neurology,University Hospital Munich (author)
  • University Hospital MunichLudwig-Maximilian University of Munich (creator_code:org_t)

Related titles

  • In:Circulation Research125:8, s. 773-7820009-7330

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