Characterization of hippocampal subfields using ex vivo MRI and histology data : Lessons for in vivo segmentation

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MARC

de Flores, RobinUniversity of Pennsylvania (author)

Characterization of hippocampal subfields using ex vivo MRI and histology data : Lessons for in vivo segmentation

Article/chapterEnglish2020

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2019-11
Wiley,2020
10 s.

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LIBRIS-ID:oai:lup.lub.lu.se:24d11f6d-ca9a-4cd7-99b5-6d6e3c536094
https://lup.lub.lu.se/record/24d11f6d-ca9a-4cd7-99b5-6d6e3c536094URI
https://doi.org/10.1002/hipo.23172DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a postmortem dataset containing nine specimens of subjects with and without dementia, which underwent a 9.4 T MRI and histological processing. Postmortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered annotated histological sections. We focus on the following topics: the order of appearance of subfields, the location of subfields relative to macroanatomical features, the location of subfields in the uncus and tail and the composition of the dark band, a hypointense layer visible in T2-weighted MRI. Our main findings are that: (a) there is a consistent order of appearance of subfields in the hippocampal head, (b) the composition of subfields is not consistent in the anterior uncus, but more consistent in the posterior uncus, (c) the dark band consists only of the CA-stratum lacunosum moleculare, not the strata moleculare of the dentate gyrus, (d) the subiculum/CA1 border is located at the middle of the width of the hippocampus in the body in coronal plane, but moves in a medial direction from anterior to posterior, and (e) the variable location and composition of subfields in the hippocampal tail can be brought back to a body-like appearance when reslicing the MRI scan following the curvature of the tail. Our findings and this publicly available dataset will hopefully improve anatomical accuracy of future hippocampal subfield segmentation protocols.

Subject headings and genre

TEKNIK OCH TEKNOLOGIER Medicinteknik Medicinsk bildbehandling hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering Medical Image Processing hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
ex vivo
hippocampal subfields
histology
in vivo
MRI
segmentation

Added entries (persons, corporate bodies, meetings, titles ...)

Berron, DavidLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)da1401be (author)
Ding, Song LinAllen Institute for Brain Science,Guangzhou Medical University (author)
Ittyerah, RanjitUniversity of Pennsylvania (author)
Pluta, John B.University of Pennsylvania (author)
Xie, LongUniversity of Pennsylvania (author)
Adler, Daniel H.University of Pennsylvania (author)
Robinson, John L.University of Pennsylvania (author)
Schuck, TheresaUniversity of Pennsylvania (author)
Trojanowski, John Q.University of Pennsylvania (author)
Grossman, MurrayUniversity of Pennsylvania (author)
Liu, WeixiaUniversity of Pennsylvania (author)
Pickup, StephenUniversity of Pennsylvania (author)
Das, Sandhitsu R.University of Pennsylvania (author)
Wolk, David A.University of Pennsylvania (author)
Yushkevich, Paul A.University of Pennsylvania (author)
Wisse, Laura E.M.University of Pennsylvania(Swepub:lu)la3343wi (author)
University of PennsylvaniaKlinisk minnesforskning (creator_code:org_t)

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In:Hippocampus: Wiley30:6, s. 545-5641050-96311098-1063

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By the author/editor: de Flores, Robin; Berron, David; Ding, Song Lin; Ittyerah, Ranjit; Pluta, John B.; Xie, Long; show more...; Adler, Daniel H.; Robinson, John L ...; Schuck, Theresa; Trojanowski, Joh ...; Grossman, Murray; Liu, Weixia; Pickup, Stephen; Das, Sandhitsu R ...; Wolk, David A.; Yushkevich, Paul ...; Wisse, Laura E.M ...; show less...

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ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Medical Engineer ...; and Medical Image Pr ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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