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Abdominal symptoms ...
Abdominal symptoms and cancer in the Abdomen : Prospective cohort study in European primary care
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- Holtedahl, Knut (författare)
- UiT The Arctic University of Norway, Tromsø
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- Hjertholm, Peter (författare)
- Aarhus University,Aarhus Univ, Denmark
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- Borgquist, Lars (författare)
- Linköpings universitet,Linköping University,Avdelningen för samhällsmedicin,Medicinska fakulteten
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- Donker, Gé A. (författare)
- Netherlands Institute for Health Services Research,NIVEL Primary Care Database, Netherlands
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- Buntinx, Frank (författare)
- Maastricht University,Catholic University of Leuven,Katholieke Univ Leuven, Belgium; Maastricht Univ, Netherlands
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- Weller, David (författare)
- University of Edinburgh,Univ Edinburgh, Scotland
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- Braaten, Tonje (författare)
- UiT The Arctic University of Norway, Tromsø
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- Månsson, Jörgen, 1958 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Strandberg, Eva Lena (författare)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Lund Univ, Sweden
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- Campbell, Christine (författare)
- University of Edinburgh,Univ Edinburgh, Scotland,NIVEL Primary Care Database, Netherlands,Netherlands Institute for Health Services Research
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- Korevaar, Joke C. (författare)
- Netherlands Institute for Health Services Research
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- Parajuli, Ranjan (författare)
- UiT The Arctic University of Norway, Tromsø
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(creator_code:org_t)
- ROYAL COLL GENERAL PRACTITIONERS, 2018
- 2018
- Engelska.
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Ingår i: British Journal of General Practice. - : ROYAL COLL GENERAL PRACTITIONERS. - 0960-1643 .- 1478-5242. ; 68:670, s. 301-310
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background: Different abdominal symptoms may signal cancer, but their role is unclear. Aim: To examine associations between abdominal symptoms and subsequent cancer diagnosed in the abdominal region. Design and setting: Prospective cohort study comprising 493 GPs from surgeries in Norway, Denmark, Sweden, Scotland, Belgium, and the Netherlands. Method: Over a 10-day period, the GPs recorded consecutive consultations and noted: patients who presented with abdominal symptoms pre-specified on the registration form; additional data on non-specific symptoms; and features of the consultation. Eight months later, data on all cancer diagnoses among all study patients in the participating general practices were requested from the GPs. Results: Consultations with 61 802 patients were recorded and abdominal symptoms were documented in 6264 (10.1%) patients. Malignancy, both abdominal and non-abdominal, was subsequently diagnosed in 511 patients (0.8%). Among patients with a new cancer in the abdomen (n = 251), 175 (69.7%) were diagnosed within 180 days after consultation. In a multivariate model, the highest sex- and age-adjusted hazard ratio (HR) was for the single symptom of rectal bleeding (HR 19.1, 95% confidence interval = 8.7 to 41.7). Positive predictive values of >3% were found for macroscopic haematuria, rectal bleeding, and involuntary weight loss, with variations according to age and sex. The three symptoms relating to irregular bleeding had particularly high specificity in terms of colorectal, uterine, and bladder cancer. Conclusions: A patient with undiagnosed cancer may present with symptoms or no symptoms. Irregular bleeding must always be explained. Abdominal pain occurs with all types of abdominal cancer and several symptoms may signal colorectal cancer. The findings are important as they influence how GPs think and act, and how they can contribute to an earlier diagnosis of cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cancer
- Early diagnosis
- General practice
- Proportional hazard models
- Symptoms
- cancer; early diagnosis; general practice; proportional hazard models; symptoms
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Holtedahl, Knut
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Hjertholm, Peter
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Borgquist, Lars
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Donker, Gé A.
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Buntinx, Frank
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Weller, David
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Braaten, Tonje
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Månsson, Jörgen, ...
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Strandberg, Eva ...
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Campbell, Christ ...
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Korevaar, Joke C ...
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Parajuli, Ranjan
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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British Journal ...
- Av lärosätet
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Lunds universitet
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Linköpings universitet
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