Sökning: WFRF:(Höglund L.)
> (1985-1989) >
Interaction between...
Interaction between isoniazid and theophylline
-
- Höglund, P (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Kliniska studier vid kronisk njursjukdom (CKD),Proteasinhibitorforskning,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Clinical studies in CKD,Protease Inhibitor Research
-
Nilsson, L G (författare)
-
Paulsen, Otto (författare)
-
(creator_code:org_t)
- 1987
- 1987
- Engelska.
-
Ingår i: European Journal of Respiratory Diseases. - 0106-4339. ; 70:2, s. 6-110
- Relaterad länk:
-
https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- Metabolic interactions between theophylline and several other drugs have been described in a number of studies. They may be of importance because of the narrow therapeutic range of theophylline. A significant risk for interactions has been considered to exist only with drugs metabolized by oxidative enzyme systems, and thus is not expected to occur with isoniazid. However, an increased clearance of theophylline with oral isoniazid medication has been reported. On the other hand, we found a significant increase in plasma levels of intravenously infused theophylline, and a corresponding decrease in plasma clearance of theophylline, when isoniazid was administered orally, compared to similar infusions in these individuals without concomitant isoniazid medication. The effect was seen irrespective of acetylator status. In five of the seven subjects an increase of isoniazid half-life and AUC was seen with theophylline, but this increase was not statistically significant.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Acetylation
- Adult
- Drug Interactions
- Female
- Humans
- Isoniazid
- Kinetics
- Male
- Middle Aged
- Theophylline
- Journal Article
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas