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Impaired meningeal ...
Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease
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- Ding, Xue Bing (författare)
- Zhengzhou University,First Affiliated Hospital of Zhengzhou University
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- Wang, Xin Xin (författare)
- First Affiliated Hospital of Zhengzhou University,Zhengzhou University
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- Xia, Dan Hao (författare)
- Zhengzhou University,First Affiliated Hospital of Zhengzhou University
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- Liu, Han (författare)
- First Affiliated Hospital of Zhengzhou University,Zhengzhou University
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- Tian, Hai Yan (författare)
- First Affiliated Hospital of Zhengzhou University,Zhengzhou University
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- Fu, Yu (författare)
- Zhengzhou University,First Affiliated Hospital of Zhengzhou University
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- Chen, Yong Kang (författare)
- Zhengzhou University,First Affiliated Hospital of Zhengzhou University
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- Qin, Chi (författare)
- First Affiliated Hospital of Zhengzhou University,Zhengzhou University
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- Wang, Jiu Qi (författare)
- Zhengzhou University,First Affiliated Hospital of Zhengzhou University
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- Xiang, Zhi (författare)
- Zhengzhou University,First Affiliated Hospital of Zhengzhou University
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- Zhang, Zhong Xian (författare)
- Zhengzhou University
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- Cao, Qin Chen (författare)
- First Affiliated Hospital of Zhengzhou University
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Wang, Wei (författare)
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- Li, Jia Yi (författare)
- Lund University,Lunds universitet,Neural plasticitet och reparation,Forskargrupper vid Lunds universitet,Neural Plasticity and Repair,Lund University Research Groups,China Medical University, Shenyang
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- Wu, Erxi (författare)
- Dell Medical School,Baylor Scott and White Hospital
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- Tang, Bei Sha (författare)
- Central South University, China
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- Ma, Ming Ming (författare)
- Zhengzhou University
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- Teng, Jun Fang (författare)
- First Affiliated Hospital of Zhengzhou University,Zhengzhou University
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- Wang, Xue Jing (författare)
- First Affiliated Hospital of Zhengzhou University,Zhengzhou University
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(creator_code:org_t)
- 2021-01-18
- 2021
- Engelska 8 s.
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:3, s. 411-418
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (PD). However, there is no direct evidence in humans to support this role1–5. In this study, we used dynamic contrast-enhanced magnetic resonance imaging to assess meningeal lymphatic flow in cognitively normal controls and patients with idiopathic PD (iPD) or atypical Parkinsonian (AP) disorders. We found that patients with iPD exhibited significantly reduced flow through the meningeal lymphatic vessels (mLVs) along the superior sagittal sinus and sigmoid sinus, as well as a notable delay in deep cervical lymph node perfusion, compared to patients with AP. There was no significant difference in the size (cross-sectional area) of mLVs in patients with iPD or AP versus controls. In mice injected with α-synuclein (α-syn) preformed fibrils, we showed that the emergence of α-syn pathology was followed by delayed meningeal lymphatic drainage, loss of tight junctions among meningeal lymphatic endothelial cells and increased inflammation of the meninges. Finally, blocking flow through the mLVs in mice treated with α-syn preformed fibrils increased α-syn pathology and exacerbated motor and memory deficits. These results suggest that meningeal lymphatic drainage dysfunction aggravates α-syn pathology and contributes to the progression of PD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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Ding, Xue Bing
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Wang, Xin Xin
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Xia, Dan Hao
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Liu, Han
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Tian, Hai Yan
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Fu, Yu
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Chen, Yong Kang
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Qin, Chi
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Wang, Jiu Qi
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Xiang, Zhi
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Zhang, Zhong Xia ...
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Cao, Qin Chen
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Wang, Wei
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Li, Jia Yi
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Wu, Erxi
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Tang, Bei Sha
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Ma, Ming Ming
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Teng, Jun Fang
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Wang, Xue Jing
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