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- Johansson, AnnLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH (author)
Pre-treatment dosimetry for interstitial photodynamic therapy
- Article/chapterEnglish2005
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- SPIE,2005
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- LIBRIS-ID:oai:lup.lub.lu.se:2618ba75-1aa0-4e81-931d-3358649c4899
- https://lup.lub.lu.se/record/615227URI
- https://doi.org/10.1117/12.633089DOI
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- Language:English
- Summary in:English
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- A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that is capable of both delivering the therapeutic irradiation and measuring parameters of relevance to treatment monitoring, knowledge has been gained on temporal variations of tissue light absorption, sensitizer photobleaching and tissue oxygenation status. We speculate on how variations in these three parameters can be implemented in a crude pre-treatment dosimetry model for photodynamic therapy
Subject headings and genre
- NATURVETENSKAP Fysik Atom- och molekylfysik och optik hsv//swe
- NATURAL SCIENCES Physical Sciences Atom and Molecular Physics and Optics hsv//eng
- tissue oxygenation
- sensitizer photobleaching
- tissue light absorption
- finite element method
- genetic algorithm
- dosimetry
- interstitial photodynamic therapy
Added entries (persons, corporate bodies, meetings, titles ...)
- Hjelm, J (author)
- Eriksson, A (author)
- Andersson-Engels, StefanLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fysi-san (author)
- AtomfysikFysiska institutionen (creator_code:org_t)
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- In:Proceedings of the SPIE - The International Society for Optical Engineering: SPIE5863:1, s. 1-586301996-756X0277-786X
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