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Psychiatric disorde...
Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme
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- Frederiksen, Line Elmerdahl (författare)
- Danish Cancer Society
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- Erdmann, Friederike (författare)
- Danish Cancer Society,Universitätsmedizin Mainz
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- Mader, Luzius (författare)
- Danish Cancer Society
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- Mogensen, Hanna (författare)
- Karolinska Institutet,Karolinska Institute
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- Pedersen, Camilla (författare)
- Danish Cancer Society
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- Kenborg, Line (författare)
- Danish Cancer Society
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Bautz, Andrea (författare)
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- Talbäck, Mats (författare)
- Karolinska Institutet,Karolinska Institute
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- Hirvonen, Elli (författare)
- Finnish Cancer Registry
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- Nielsen, Thomas Tjørnelund (författare)
- Danish Cancer Society
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- Andersen, Elisabeth Anne Wreford (författare)
- Danish Cancer Society
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- Holmqvist, Anna Sällfors (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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Jørgensen, Ole Sylvester (författare)
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- Jepsen, Jens Richardt Møllegaard (författare)
- University of Copenhagen
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- Malila, Nea (författare)
- Finnish Cancer Registry
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- Hasle, Henrik (författare)
- Aarhus University Hospital
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- Madanat-Harjuoja, Laura (författare)
- Dana-Farber Cancer Institute,Finnish Cancer Registry
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- Feychting, Maria (författare)
- Karolinska Institutet,Karolinska Institute
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- Winther, Jeanette Falck (författare)
- Aarhus University Hospital,Danish Cancer Society
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Kroyer, A (författare)
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(creator_code:org_t)
- 2022
- 2022
- Engelska 11 s.
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Ingår i: The Lancet Psychiatry. - 2215-0366 .- 2215-0374. ; 69
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: A childhood cancer diagnosis and treatment-induced somatic late effects can affect the long-term mental health of survivors. We aimed to explore whether childhood cancer survivors are at higher risk of psychiatric disorders later in life than their siblings and the general population. Methods: In this register-based cohort study (part of the Socioeconomic Consequences in Adult Life after Childhood Cancer [SALiCCS] research programme), we included 5-year survivors of childhood cancer diagnosed before 20 years of age between Jan 1, 1974 and Dec 31, 2011, in Denmark, Finland, and Sweden. In Denmark and Sweden, 94·7% of individuals were born in a Nordic country (ie, Denmark, Finland, Iceland, Norway, or Sweden); similar information was not available in Finland. Data on ethnicity were not collected. Survivors were compared with their siblings and randomly selected individuals from the general population who were matched to the survivors by year of birth, sex, and geographical region. We followed up our study population from 5 years after the childhood cancer diagnosis or corresponding calendar date for matched individuals (the index date) until Aug 11, 2017, and assessed information on hospital contacts for any and specific psychiatric disorders. For siblings, the index date was defined as 5 years from the date on which they were of the same age as their sibling survivor when diagnosed with cancer. Findings: The study population included 18 621 childhood cancer survivors (9934 [53·3%] males and 8687 [46·7%] females), 24 775 siblings (12 594 [50·8%] males and 12 181 [49·2%] females), and 88 630 matched individuals (47 300 [53·4%] males and 41 330 [46·6%] females). The cumulative incidence proportion of having had a psychiatric hospital contact by 30 years of age between Jan 1, 1979, and Aug 11, 2017, was 15·9% (95% CI 15·3–16·5) for childhood cancer survivors, 14·0% (13·5–14·5) for siblings, and 12·7% (12·4–12·9) for matched individuals. Despite a small absolute difference, survivors were at higher relative risk of any psychiatric hospital contact than their siblings (1·39, 1·31–1·48) and matched individuals (hazard ratio 1·34, 95% CI 1·28–1·39). The higher risk persisted at the age of 50 years. Survivors had a higher burden of recurrent psychiatric hospital contacts and had more hospital contacts for different psychiatric disorders than their siblings and the matched individuals. Interpretation: Childhood cancer survivors are at higher long-term risk of psychiatric disorders than their siblings and matched individuals from the general population. To improve mental health and the overall quality of life after childhood cancer, survivorship care should include a focus on early signs of mental health problems, especially among high-risk groups of survivors. Funding: NordForsk, Aarhus University, Swedish Childhood Cancer Foundation, Danish Health Foundation, and Swiss National Science Foundation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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Frederiksen, Lin ...
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Erdmann, Frieder ...
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Mader, Luzius
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Mogensen, Hanna
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Pedersen, Camill ...
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Kenborg, Line
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Bautz, Andrea
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Talbäck, Mats
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Hirvonen, Elli
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Nielsen, Thomas ...
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Andersen, Elisab ...
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Holmqvist, Anna ...
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Jørgensen, Ole S ...
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Jepsen, Jens Ric ...
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Malila, Nea
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Hasle, Henrik
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Madanat-Harjuoja ...
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Feychting, Maria
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Winther, Jeanett ...
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Kroyer, A
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Lunds universitet
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Karolinska Institutet