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Three-dimensional m...
Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe
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- Yushkevich, Paul A. (author)
- University of Pennsylvania
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- Muñoz López, Mónica (author)
- University of Castilla La Mancha
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- Iñiguez De Onzoño Martin, María Mercedes (author)
- University of Castilla La Mancha
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- Ittyerah, Ranjit (author)
- University of Pennsylvania
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- Lim, Sydney (author)
- University of Pennsylvania
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- Ravikumar, Sadhana (author)
- University of Pennsylvania
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- Bedard, Madigan L. (author)
- University of Pennsylvania
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- Pickup, Stephen (author)
- University of Pennsylvania
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- Liu, Weixia (author)
- University of Pennsylvania
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- Wang, Jiancong (author)
- University of Pennsylvania
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- Hung, Ling Yu (author)
- University of Pennsylvania
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- Lasserve, Jade (author)
- University of Pennsylvania
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- Vergnet, Nicolas (author)
- University of Pennsylvania
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- Xie, Long (author)
- University of Pennsylvania
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- Dong, Mengjin (author)
- University of Pennsylvania
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- Cui, Salena (author)
- University of Pennsylvania
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- McCollum, Lauren (author)
- University of Pennsylvania
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- Robinson, John L. (author)
- University of Pennsylvania
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- Schuck, Theresa (author)
- University of Pennsylvania
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- De Flores, Robin (author)
- Institut Gustave Roussy
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- Grossman, Murray (author)
- University of Pennsylvania
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- Tisdall, M. Dylan (author)
- University of Pennsylvania
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- Prabhakaran, Karthik (author)
- University of Pennsylvania
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- Mizsei, Gabor (author)
- University of Pennsylvania
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- Das, Sandhitsu R. (author)
- University of Pennsylvania
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- Artacho-Pérula, Emilio (author)
- University of Castilla La Mancha
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- Del Mar Arroyo Jiménez, Marl'a (author)
- University of Castilla La Mancha
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- Marcos Raba, Marl'a Pilar (author)
- University of Castilla La Mancha
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- Molina Romero, Francisco Javier (author)
- University of Castilla La Mancha
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- Cebada Sánchez, Sandra (author)
- University of Castilla La Mancha
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- Delgado González, José Carlos (author)
- University of Castilla La Mancha
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- De La Rosa-Prieto, Carlos (author)
- University of Castilla La Mancha
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- Córcoles Parada, Marta (author)
- University of Castilla La Mancha
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- Lee, Edward B. (author)
- University of Pennsylvania
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- Trojanowski, John Q. (author)
- University of Pennsylvania
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- Ohm, Daniel T. (author)
- University of Pennsylvania
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- Wisse, Laura E.M. (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Wolk, David A. (author)
- University of Pennsylvania
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- Irwin, David J. (author)
- University of Pennsylvania
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- Insausti, Ricardo (author)
- University of Castilla La Mancha
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(creator_code:org_t)
- 2021-07-14
- 2021
- English 14 s.
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In: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 144:9, s. 2784-2797
- Related links:
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of neurofibrillary tangle progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in Alzheimer's disease, is based on conventional two-dimensional histology studies that only sample the brain sparsely. To address this limitation, ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe specimens (age 75.3 ± 11.4 years, range 45 to 93) were used to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe at individual and group levels. Group-level maps were obtained in the space of an in vivo brain template, and neurofibrillary tangles were measured in specific anatomical regions defined in this template. Three-dimensional maps of neurofibrillary tangle burden revealed significant variation along the anterior-posterior axis. While early neurofibrillary tangle pathology is thought to be confined to the transentorhinal region, we found similar levels of burden in this region and other medial temporal lobe subregions, including amygdala, temporopolar cortex, and subiculum/cornu ammonis 1 hippocampal subfields. Overall, the three-dimensional maps of neurofibrillary tangle burden presented here provide more complete information about the distribution of this neurodegenerative pathology in the region of the cortex where it first emerges in Alzheimer's disease, and may help inform the field about the patterns of pathology spread, as well as support development and validation of neuroimaging biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- medial temporal lobe
- neurodegeneration
- neurofibrillary tangles
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Yushkevich, Paul ...
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Muñoz López, Món ...
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Iñiguez De Onzoñ ...
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Ittyerah, Ranjit
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Lim, Sydney
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Ravikumar, Sadha ...
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show more...
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Bedard, Madigan ...
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Pickup, Stephen
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Liu, Weixia
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Wang, Jiancong
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Hung, Ling Yu
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Lasserve, Jade
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Vergnet, Nicolas
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Xie, Long
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Dong, Mengjin
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Cui, Salena
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McCollum, Lauren
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Robinson, John L ...
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Schuck, Theresa
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De Flores, Robin
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Grossman, Murray
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Tisdall, M. Dyla ...
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Prabhakaran, Kar ...
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Mizsei, Gabor
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Das, Sandhitsu R ...
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Artacho-Pérula, ...
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Del Mar Arroyo J ...
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Marcos Raba, Mar ...
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Molina Romero, F ...
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Cebada Sánchez, ...
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Delgado González ...
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De La Rosa-Priet ...
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Córcoles Parada, ...
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Lee, Edward B.
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Trojanowski, Joh ...
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Ohm, Daniel T.
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Wisse, Laura E.M ...
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Wolk, David A.
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Irwin, David J.
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Insausti, Ricard ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Brain
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Lund University