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  • Koletzko, SibylleUniversity Hospital Munich (författare)

Caesarean Section on The Risk of Celiac Disease in the Offspring : The Teddy Study

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:26b0795b-a971-4ede-8ef9-b01fb51286dc
  • https://lup.lub.lu.se/record/26b0795b-a971-4ede-8ef9-b01fb51286dcURI
  • https://doi.org/10.1097/MPG.0000000000001682DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • OBJECTIVE:: Caesarean section (C-section) is associated with various immune-mediated diseases in the offspring. We investigated the relationship between mode of delivery and celiac disease (CD) and CD autoimmunity (CDA) in a multinational birth cohort. METHODS:: From 2004 to 2010 infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in The Environmental Determinants for Diabetes in the Young (TEDDY) study. Children were annually screened for transglutaminase autoantibodies, if positive re-tested after 3–6 months and those persistently positive defined as CDA. Associations of C-section with maternal (age, education level, parity, pre-pregnancy weight, diabetes, smoking, weight gain during pregnancy) and child characteristics (gestational age, birth weight) were examined by Fisherʼs exact test or Wilcoxon rank-sum test. Hazard ratios (HRs) for CDA or CD were calculated by Cox proportional hazard regression models. RESULTS:: Of 6,087 analyzed singletons 1600 (26%) were born by C-section (Germany 38%, US 37%, Finland 18%, Sweden 16%), the remaining vaginally without instrumental support; 979 (16%) had developed CDA and 343 (6%) CD. C-section was associated with lower risk for CDA (HR?=?0.85, [95% CI 0.73, 0.99], p?=?0.032) and CD (HR?=?0.75, [95% CI 0.58, 0.98], p?=?0.034). After adjusting for country, sex, HLA-genotype, CD in family, maternal education and breastfeeding duration, significance was lost for CDA (HR?=?0.91, [95% CI 0.78, 1.06], p?=?0.20) and CD (HR?=?0.85, [95% CI 0.65, 1.11], p?=?0.24). Pre-surgical ruptured membranes had no influence on CDA or CD development. CONCLUSION:: C-section is not associated with increased risk for CDA or CD in the offspring.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lee, Hye-SeungUniversity of South Florida (författare)
  • Beyerlein, AndreasTechnical University of Munich (författare)
  • Aronsson, Carin A.Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)smi-can (författare)
  • Hummel, MichaelTechnical University of Munich (författare)
  • Liu, EdwinUniversity of Colorado (författare)
  • Simell, VilleUniversity of Turku (författare)
  • Kurppa, KalleUniversity of Tampere (författare)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale (författare)
  • Hagopian, WilliamPacific Northwest Research Institute (författare)
  • Rewers, MarianTechnical University of Munich (författare)
  • She, Jin-XiongMedical College of Georgia (författare)
  • Simell, OlliUniversity of Turku,Turku University Hospital (författare)
  • Toppari, JormaTurku University Hospital,University of Turku (författare)
  • Ziegler, Anette G.University of Colorado (författare)
  • Krischer, JeffreyUniversity of South Florida (författare)
  • Agardh, DanielLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)med-dia (författare)
  • University Hospital MunichUniversity of South Florida (creator_code:org_t)
  • TEDDY Study Group

Sammanhörande titlar

  • Ingår i:Journal of Pediatric Gastroenterology and Nutrition66:3, s. 417-4240277-2116

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