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Genetic regulation ...
Genetic regulation of spermine oxidase activity and cancer risk : a Mendelian randomization study
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- Fadista, João (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Danish Serum Institute, Copenhagen
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- Yakimov, Victor (author)
- Danish Serum Institute, Copenhagen
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- Võsa, Urmo (author)
- University of Tartu
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- Hansen, Christine S. (author)
- Danish Serum Institute, Copenhagen
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- Kasela, Silva (author)
- University of Tartu
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- Skotte, Line (author)
- Danish Serum Institute, Copenhagen
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- Geller, Frank (author)
- Danish Serum Institute, Copenhagen
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- Courraud, Julie (author)
- Danish Serum Institute, Copenhagen
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- Esko, Tõnu (author)
- Broad Institute
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- Kukuškina, Viktorija (author)
- University of Tartu
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- Buil, Alfonso (author)
- Lundbeck Foundation Initiative for Integrative Psychiatric Research
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- Melbye, Mads (author)
- Stanford University,University of Copenhagen
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- Werge, Thomas M. (author)
- Lundbeck Foundation Initiative for Integrative Psychiatric Research
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- Hougaard, David M. (author)
- Danish Serum Institute, Copenhagen
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- Milani, Lili (author)
- University of Tartu
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- Bybjerg-Grauholm, Jonas (author)
- Danish Serum Institute, Copenhagen
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- Cohen, Arieh S. (author)
- Danish Serum Institute, Copenhagen
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- Feenstra, Bjarke (author)
- Danish Serum Institute, Copenhagen
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(creator_code:org_t)
- 2021-08-31
- 2021
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
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- Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to identify genetic variants associated with regulation of SMOX activity. Replication analysis was performed in two datasets of SMOX gene expression. We then did a Mendelian randomization analysis by testing the association between the SMOX genetic instrument and neuroblastoma, gastric, lung, breast, prostate, and colorectal cancers using GWAS summary statistics. GWAS of spermidine/spermine ratio identified SMOX locus (P = 1.34 × 10–49) explaining 32% of the variance. The lead SNP rs1741315 was also associated with SMOX gene expression in newborns (P = 8.48 × 10–28) and adults (P = 2.748 × 10–8) explaining 37% and 6% of the variance, respectively. Genetically determined SMOX activity was not associated with neuroblastoma, gastric, lung, breast, prostate nor colorectal cancer (P > 0.05). A PheWAS of rs1741315 did not reveal any relevant associations. Common genetic variation in the SMOX gene was strongly associated with SMOX activity in newborns, and less strongly in adults. Genetic down-regulation of SMOX was not significantly associated with lower odds of neuroblastoma, gastric, lung, breast, prostate and colorectal cancer. These results may inform studies of SMOX inhibition as a target for chemoprevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
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- By the author/editor
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Fadista, João
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Yakimov, Victor
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Võsa, Urmo
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Hansen, Christin ...
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Kasela, Silva
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Skotte, Line
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show more...
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Geller, Frank
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Courraud, Julie
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Esko, Tõnu
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Kukuškina, Vikto ...
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Buil, Alfonso
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Melbye, Mads
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Werge, Thomas M.
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Hougaard, David ...
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Milani, Lili
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Bybjerg-Grauholm ...
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Cohen, Arieh S.
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Feenstra, Bjarke
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Lund University