Evaluation of circulating immune complex-like material for development of skin reactions in connection with penicillin therapy

The levels of immune complex-like material in serum from 18 patients in connection with skin eruptions appearing during penicillin therapy were determined with a modified ELISA. Immune complex-like material could only be shown in the serum of 3 out of the 17 patients. However, according to ELISA results, the complexes appeared without the simultaneous presence of penicilloyl-specific antibodies. Neither could penicilloyl-specific antibodies be recorded in 9 patient treated with parenteral penicillin without adverse reactions. 3 of these patients had immune complex-like material in their serum. It was concluded that immune complex-like material with penicilloyl specificity is not likely to contribute to the development of skin eruptions often seen in connection with penicillin treatment.

Bjursten, Lars MagnusLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)exp-lbj (author)
Hanson, L A (author)
Lidin-Janson, G (author)
Mobacken, H (author)
Belin, L (author)
Institutionen för experimentell medicinsk vetenskapMedicinska fakulteten (creator_code:org_t)

In:International Archives of Allergy and Applied Immunology64:2, s. 195-2000020-5915

By the author/editor: Ahlstedt, S; Bjursten, Lars M ...; Hanson, L A; Lidin-Janson, G; Mobacken, H; Belin, L

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