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Early life exposure...
Early life exposure to mercury and relationships with telomere length and mitochondrial DNA content in European children
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- Lozano, Manuel (författare)
- University of Valencia
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- McEachan, Rosemary R.C. (författare)
- Bradford Institute for Health Research
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- Wright, John (författare)
- Bradford Institute for Health Research
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Yang, Tiffany C. (författare)
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- Dow, Courtney (författare)
- Sorbonne Paris Nord University
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- Kadawathagedara, Manik (författare)
- Sorbonne Paris Nord University
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- Lepeule, Johanna (författare)
- University Grenoble Alpes
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- Bustamante, Mariona (författare)
- Pompeu Fabra University,CIBER Epidemiology and Public Health (CIBERESP)
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- Maitre, Lea (författare)
- Pompeu Fabra University,CIBER Epidemiology and Public Health (CIBERESP)
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- Vrijheid, Martine (författare)
- Pompeu Fabra University,CIBER Epidemiology and Public Health (CIBERESP)
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- Brantsæter, Anne Lise (författare)
- Norwegian Institute of Public Health
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- Meltzer, Helle Margrete (författare)
- Norwegian Institute of Public Health
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- Bempi, Vasiliki (författare)
- University of Crete Medical School
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- Roumeliotaki, Theano (författare)
- University of Crete Medical School
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- Thomsen, Cathrine (författare)
- Norwegian Institute of Public Health
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- Nawrot, Tim (författare)
- Catholic University of Leuven
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- Broberg, Karin (författare)
- Karolinska Institute,Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LTH profilområde: Aerosoler,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH
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- Llop, Sabrina (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Science of the Total Environment. - 0048-9697 .- 1879-1026. ; 932
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Telomere length (TL) and mitochondrial function expressed as mitochondrial DNA copy number (mtDNAcn) are biomarkers of aging and oxidative stress and inflammation, respectively. Methylmercury (MeHg), a common pollutant in fish, induces oxidative stress. We hypothesized that elevated oxidative stress from exposure to MeHg decreases mtDNAcn and shortens TL. Methods: Study participants are 6–11-year-old children from the HELIX multi-center birth cohort study, comprising six European countries. Prenatal and postnatal total mercury (THg) concentrations were measured in blood samples, TL and mtDNAcn were determined in child DNA. Covariates and confounders were obtained by questionnaires. Robust regression models were run, considering sociodemographic and lifestyle covariates, as well as fish consumption. Sex, ethnicity, and fish consumption interaction models were also run. Results: We found longer TL with higher pre- and postnatal THg blood concentrations, even at low-level THg exposure according to the RfD proposed by the US EPA. The prenatal association showed a significant linear relationship with a 3.46 % increase in TL for each unit increased THg. The postnatal association followed an inverted U-shaped marginal non-linear relationship with 1.38 % an increase in TL for each unit increased THg until reaching a cut-point at 0.96 μg/L blood THg, from which TL attrition was observed. Higher pre- and postnatal blood THg concentrations were consistently related to longer TL among cohorts and no modification effect of fish consumption nor children's sex was observed. No association between THg exposure and mtDNAcn was found. Discussion: We found evidence that THg is associated with TL but the associations seem to be time- and concentration-dependent. Further studies are needed to clarify the mechanism behind the telomere changes of THg and related health effects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Fish consumption
- Mercury
- Mitochondrial DNA content
- Oxidative stress
- Telomere length
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Lozano, Manuel
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McEachan, Rosema ...
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Wright, John
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Yang, Tiffany C.
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Dow, Courtney
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Kadawathagedara, ...
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visa fler...
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Lepeule, Johanna
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Bustamante, Mari ...
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Maitre, Lea
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Vrijheid, Martin ...
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Brantsæter, Anne ...
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Meltzer, Helle M ...
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Bempi, Vasiliki
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Roumeliotaki, Th ...
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Thomsen, Cathrin ...
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Nawrot, Tim
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Broberg, Karin
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Llop, Sabrina
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