Epithelial–mesenchymal transition, a spectrum of states : Role in lung development, homeostasis, and disease

Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346–358, 2018.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
chronic pulmonary obstructive disease (COPD)
epithelial–mesenchymal transition (EMT)
hybrid epithelial/mesenchymal
idiopathic pulmonary fibrosis (IPF)
lung cancer

Ward, ChrisUniversity of Newcastle upon Tyne (author)
Eapen, Mathew SujiUniversity of Tasmania (author)
Myers, StephenUniversity of Tasmania (author)
Hallgren, OskarLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Department of Experimental Medical Science,Faculty of Medicine,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund(Swepub:lu)mmb-oha (author)
Levine, HerbertRice University (author)
Sohal, Sukhwinder SinghUniversity of Tasmania (author)
Rice UniversityUniversity of Newcastle upon Tyne (creator_code:org_t)

By the author/editor: Jolly, Mohit Kum ...; Ward, Chris; Eapen, Mathew Su ...; Myers, Stephen; Hallgren, Oskar; Levine, Herbert; show more...; Sohal, Sukhwinde ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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