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Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes

Phillip, Moshe (author)
Tel-Aviv University
Achenbach, Peter (author)
Technical University of Munich
Addala, Ananta (author)
Stanford University
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Albanese-O'Neill, Anastasia (author)
Battelino, Tadej (author)
University of Ljubljana
Bell, Kirstine J (author)
University of Sydney
Besser, Rachel E J (author)
University of Oxford
Bonifacio, Ezio (author)
Dresden University of Technology
Colhoun, Helen M (author)
University of Edinburgh
Couper, Jennifer J (author)
University of Adelaide
Craig, Maria E (author)
University of Sydney
Danne, Thomas (author)
de Beaufort, Carine (author)
Dovc, Klemen (author)
Driscoll, Kimberly A (author)
Dutta, Sanjoy (author)
Ebekozien, Osagie (author)
Larsson, Helena Elding (author)
Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital
Feiten, Daniel J (author)
Frohnert, Brigitte I (author)
Gabbay, Robert A (author)
Gallagher, Mary P (author)
Greenbaum, Carla J (author)
Griffin, Kurt J (author)
Hagopian, William (author)
Haller, Michael J (author)
Hendrieckx, Christel (author)
Hendriks, Emile (author)
Holt, Richard I G (author)
Hughes, Lucille (author)
Ismail, Heba M (author)
Jacobsen, Laura M (author)
Johnson, Suzanne B (author)
Kolb, Leslie E (author)
Kordonouri, Olga (author)
Lange, Karin (author)
Lash, Robert W (author)
Lernmark, Åke (author)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
Libman, Ingrid (author)
Lundgren, Markus (author)
Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad
Maahs, David M (author)
Marcovecchio, M Loredana (author)
Mathieu, Chantal (author)
Miller, Kellee M (author)
O'Donnell, Holly K (author)
Oron, Tal (author)
Patil, Shivajirao P (author)
Pop-Busui, Rodica (author)
Rewers, Marian J (author)
Rich, Stephen S (author)
Schatz, Desmond A (author)
Schulman-Rosenbaum, Rifka (author)
Simmons, Kimber M (author)
Sims, Emily K (author)
Skyler, Jay S (author)
Smith, Laura B (author)
Speake, Cate (author)
Steck, Andrea K (author)
Thomas, Nicholas P B (author)
Tonyushkina, Ksenia N (author)
Veijola, Riitta (author)
University of Oulu
Wentworth, John M (author)
Wherrett, Diane K (author)
Wood, Jamie R (author)
Ziegler, Anette-Gabriele (author)
DiMeglio, Linda A (author)
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 (creator_code:org_t)
English.
In: Diabetologia. - 1432-0428.
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programmes are being increasingly emphasised. Once broadly implemented, screening initiatives will identify significant numbers of islet autoantibody-positive (IAb+) children and adults who are at risk of (confirmed single IAb+) or living with (multiple IAb+) early-stage (stage 1 and stage 2) type 1 diabetes. These individuals will need monitoring for disease progression; much of this care will happen in non-specialised settings. To inform this monitoring, JDRF in conjunction with international experts and societies developed consensus guidance. Broad advice from this guidance includes the following: (1) partnerships should be fostered between endocrinologists and primary-care providers to care for people who are IAb+; (2) when people who are IAb+ are initially identified there is a need for confirmation using a second sample; (3) single IAb+ individuals are at lower risk of progression than multiple IAb+ individuals; (4) individuals with early-stage type 1 diabetes should have periodic medical monitoring, including regular assessments of glucose levels, regular education about symptoms of diabetes and DKA, and psychosocial support; (5) interested people with stage 2 type 1 diabetes should be offered trial participation or approved therapies; and (6) all health professionals involved in monitoring and care of individuals with type 1 diabetes have a responsibility to provide education. The guidance also emphasises significant unmet needs for further research on early-stage type 1 diabetes to increase the rigour of future recommendations and inform clinical care.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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art (subject category)
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