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Environmental expos...
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy
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- Smpokou, Evangelia Theano (author)
- University College London
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- González-Quiroz, Marvin (author)
- National Autonomous University of Nicaragua,University College London
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- Martins, Carla (author)
- National Health Institute Doutor Ricardo Jorge, Lisbon,University of Aveiro
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- Alvito, Paula (author)
- National Health Institute Doutor Ricardo Jorge, Lisbon,University of Aveiro
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- Le Blond, Jennifer (author)
- Imperial College London
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- Glaser, Jason (author)
- London School of Hygiene and Tropical Medicine,La Isla Network
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- Aragón, Aurora (author)
- National Autonomous University of Nicaragua
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- Wesseling, Catharina (author)
- Karolinska Institute,La Isla Network
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- Nitsch, Dorothea (author)
- London School of Hygiene and Tropical Medicine
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- Pearce, Neil (author)
- London School of Hygiene and Tropical Medicine
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- Norman, Jill (author)
- University College London
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- Lindh, Christian H. (author)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Morton, Jackie (author)
- Health and Safety Laboratory
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- Caplin, Ben (author)
- University College London
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(creator_code:org_t)
- 2019-09-27
- 2019
- English 7 s.
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In: Occupational and environmental medicine. - : BMJ. - 1351-0711 .- 1470-7926. ; 76:12, s. 920-926
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http://dx.doi.org/10...
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Abstract
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- Objectives There is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case-control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of characterising the associations between urinary concentrations of metals, pesticides and mycotoxins from samples collected in the first 6 months and decline in kidney function over 2 years. Methods Urine samples collected at baseline (pre-sugarcane harvest) and the first 6 month follow-up (post-sugarcane harvest) visit were tested. Twelve metals and metalloids (aluminium, total arsenic, cadmium, chromium, cobalt, copper, lead, manganese, mercury, selenium, silicon and strontium) were analysed by inductively coupled plasma-mass spectrometry. Twelve pesticides or their metabolites (2,4-dichlorophenoxyacetic acid, 3-phenoxybenzoic acid, 4-fluoro-3-phenoxybenzoic acid, chloro-3,3,3-trifluoro-1-propen-1-yl-2,2-dimethylcyclopropanecarboxylic acid, cis/trans 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, ethylenethiourea, glyphosate, 4-chloro-2-methylphenoxy acetic acid, 3-hydroxy-pyrimetanil, 5-hydroxytiabendazole, hydroxy-tebuconazole and 3,5,6-trichloro-2-pyridinol) and two mycotoxins (ochratoxin A (OTA) and citrinin (CIT)) were analysed by liquid chromatography coupled-mass spectrometry. Differences in the creatinine-corrected urinary concentrations of the measured exposures between outcome groups (participants with stable vs declining kidney function) were examined. Results Elevated levels of aluminium and total arsenic as well as metabolites of several pesticides were detected across the population. No differences were identified between the declining and stable groups in the levels of metals or pesticides tested. OTA and CIT were below the limit of detection. Conclusions The tested metals, metalloids, pesticides and mycotoxins were not associated with loss of kidney function in participants at-risk of MeN.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- chronic kidney disease of unknown origin (CKDu)
- environmental toxins
- mesoamerican nephropathy (MeN)
- nephrotoxicity
- pesticides
Publication and Content Type
- art (subject category)
- ref (subject category)
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Smpokou, Evangel ...
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González-Quiroz, ...
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Martins, Carla
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Alvito, Paula
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Le Blond, Jennif ...
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Glaser, Jason
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Aragón, Aurora
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Wesseling, Catha ...
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Nitsch, Dorothea
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Pearce, Neil
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Norman, Jill
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Lindh, Christian ...
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Morton, Jackie
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Caplin, Ben
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Occupational Hea ...
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MEDICAL AND HEAL ...
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Occupational and ...
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Lund University
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Karolinska Institutet