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How Communicating P...
How Communicating Polygenic and Clinical Risk for Atherosclerotic Cardiovascular Disease Impacts Health Behavior : an Observational Follow-up Study
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- Widén, Elisabeth (author)
- University of Helsinki
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- Junna, Nella (author)
- University of Helsinki
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- Ruotsalainen, Sanni (author)
- University of Helsinki
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- Surakka, Ida (author)
- University of Helsinki
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- Mars, Nina (author)
- University of Michigan Medical School,University of Helsinki
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- Ripatti, Pietari (author)
- Helsinki University Central Hospital,University of Helsinki
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- Partanen, Juulia J. (author)
- University of Helsinki,Folkhälsan Research Center
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- Aro, Johanna (author)
- University of Helsinki
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- Mustonen, Pekka (author)
- Duodecim Publishing Company Ltd
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- Tuomi, Tiinamaija (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Helsinki
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- Palotie, Aarno (author)
- University of Helsinki,Massachusetts General Hospital
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- Salomaa, Veikko (author)
- Finnish National Institute for Health and Welfare
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- Kaprio, Jaakko (author)
- University of Helsinki
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- Partanen, Jukka (author)
- Finnish Red Cross Blood Transfusion Service
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- Hotakainen, Kristina (author)
- Mehiläinen Oy
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- Pöllänen, Pasi (author)
- University of Helsinki
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- Ripatti, Samuli (author)
- University of Helsinki
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: Circulation: Genomic and Precision Medicine. - 2574-8300. ; 15:2, s. 003459-003459
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear. Methods: We collected a prospective cohort of 7342 individuals (64% women, mean age 56 years) and estimated their 10-year risk for atherosclerotic cardiovascular disease both by a traditional risk score and a composite score combining the effect of a polygenic risk score and clinical risk factors. We then tested how returning the personal risk information with an interactive web-tool impacted on the participants' health behavior. Results: When reassessed after 1.5 years by a clinical visit and questionnaires, 20.8% of individuals at high (>10%) 10-year atherosclerotic cardiovascular disease risk had seen a doctor, 12.4% reported weight loss, 14.2% of smokers had quit smoking, and 15.4% had signed up for health coaching online. Altogether, 42.6% of persons at high risk had made one or more health behavioral changes versus 33.5% of persons at low/average risk such that higher baseline risk predicted a favorable change (OR [CI], 1.53 [1.37-1.72] for persons at high risk versus the rest, P<0.001), with both high clinical (P<0.001) and genomic risk (OR [CI], 1.10 [1.03-1.17], P=0.003) contributing independently. Conclusions: Web-based communication of personal atherosclerotic cardiovascular disease risk-data including polygenic risk to middle-aged persons motivates positive changes in health behavior and the propensity to seek care. It supports integration of genomic information into clinical risk calculators as a feasible approach to enhance disease prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiovascular disease
- communication
- genomics
- risk factor
- weight loss
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Widén, Elisabeth
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Junna, Nella
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Ruotsalainen, Sa ...
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Surakka, Ida
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Mars, Nina
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Ripatti, Pietari
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show more...
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Partanen, Juulia ...
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Aro, Johanna
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Mustonen, Pekka
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Tuomi, Tiinamaij ...
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Palotie, Aarno
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Salomaa, Veikko
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Kaprio, Jaakko
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Partanen, Jukka
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Hotakainen, Kris ...
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Pöllänen, Pasi
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Ripatti, Samuli
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation: Gen ...
- By the university
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Lund University