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Clonal Hematopoiesi...
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Tian, RuiyiWashington University in St. Louis
(författare)
Clonal Hematopoiesis and Risk of Incident Lung Cancer
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:lup.lub.lu.se:29a338b0-5230-48cd-92ef-f43eb2d8670e
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https://lup.lub.lu.se/record/29a338b0-5230-48cd-92ef-f43eb2d8670eURI
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https://doi.org/10.1200/JCO.22.00857DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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PURPOSE: To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer. METHODS: Among 200,629 UK Biobank (UKBB) participants with whole-exome sequencing, CH was identified in a nested case-control study of 832 incident lung cancer cases and 3,951 controls (2006-2019) matched on age and year at blood draw, sex, race, and smoking status. A similar nested case-control study (141 cases/652 controls) was conducted among 27,975 participants with whole-exome sequencing in the Mass General Brigham Biobank (MGBB, 2010-2021). In parallel, we compared CH frequency in published data from 5,003 patients with solid tumor (2,279 lung cancer) who had pretreatment blood sequencing performed through Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets. RESULTS: In UKBB, the presence of CH was associated with increased risk of lung cancer (cases: 12.5% v controls: 8.7%; multivariable-adjusted odds ratio [OR], 1.36; 95% CI, 1.06 to 1.74). The association remained robust after excluding participants with chronic obstructive pulmonary disease. No significant interactions with known risk factors, including polygenic risk score and C-reactive protein, were identified. In MGBB, we observed similar enrichment of CH in lung cancer (cases: 15.6% v controls: 12.7%). The meta-analyzed OR (95% CI) of UKBB and MGBB was 1.35 (1.08 to 1.68) for CH overall and 1.61 (1.19 to 2.18) for variant allele frequencies ≥ 10%. In Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets, CH with a variant allele frequency ≥ 10% was enriched in pretreatment lung cancer compared with other tumors after adjusting for age, sex, and smoking (OR for lung v breast cancer: 1.61; 95% CI, 1.03 to 2.53). CONCLUSION: Independent of known risk factors, CH is associated with increased risk of lung cancer.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wiley, BrianWashington University in St. Louis
(författare)
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Liu, JieWashington University in St. Louis
(författare)
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Zong, XiaoyuWashington University in St. Louis
(författare)
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Truong, BuuMassachusetts Institute of Technology,Massachusetts General Hospital
(författare)
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Zhao, StephanieWashington University in St. Louis
(författare)
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Uddin, Md MesbahMassachusetts General Hospital,Massachusetts Institute of Technology
(författare)
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Niroula, AbhishekLund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Massachusetts Institute of Technology,Dana-Farber Cancer Institute(Swepub:lu)med-anu
(författare)
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Miller, Christopher A.Washington University in St. Louis
(författare)
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Mukherjee, SemantiMemorial Sloan-Kettering Cancer Center,Weill Cornell Medical College
(författare)
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Heiden, Brendan T.Washington University in St. Louis
(författare)
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Luo, JingqinWashington University in St. Louis
(författare)
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Puri, VarunWashington University in St. Louis
(författare)
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Kozower, Benjamin D.Washington University in St. Louis
(författare)
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Walter, Matthew J.Washington University in St. Louis
(författare)
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Ding, LiWashington University in St. Louis
(författare)
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Link, Daniel C.Washington University in St. Louis
(författare)
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Amos, Christopher I.Baylor College of Medicine
(författare)
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Ebert, Benjamin L.Dana-Farber Cancer Institute,Howard Hughes Medical Institute,Massachusetts Institute of Technology
(författare)
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Govindan, RamaswamyWashington University in St. Louis
(författare)
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Natarajan, PradeepHarvard Medical School,Massachusetts General Hospital,Massachusetts Institute of Technology
(författare)
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Bolton, Kelly L.Washington University in St. Louis
(författare)
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Cao, YinWashington University in St. Louis
(författare)
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Washington University in St. LouisMassachusetts Institute of Technology
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of clinical oncology : official journal of the American Society of Clinical Oncology41:7, s. 1423-14330732-183X
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Tian, Ruiyi
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Wiley, Brian
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Liu, Jie
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Zong, Xiaoyu
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Truong, Buu
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Zhao, Stephanie
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visa fler...
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Uddin, Md Mesbah
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Niroula, Abhishe ...
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Miller, Christop ...
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Mukherjee, Seman ...
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Heiden, Brendan ...
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Luo, Jingqin
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Puri, Varun
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Kozower, Benjami ...
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Walter, Matthew ...
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Ding, Li
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Link, Daniel C.
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Amos, Christophe ...
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Ebert, Benjamin ...
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Govindan, Ramasw ...
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Natarajan, Prade ...
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Bolton, Kelly L.
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Cao, Yin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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