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  • Vernino, StevenUniversity of Texas Southwestern Medical Center (author)

Postural orthostatic tachycardia syndrome (POTS) : State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier BV,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:2a43db30-dc2d-4e5e-82f3-fb7b7a9fe0c4
  • https://lup.lub.lu.se/record/2a43db30-dc2d-4e5e-82f3-fb7b7a9fe0c4URI
  • https://doi.org/10.1016/j.autneu.2021.102828DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Postural orthostatic tachycardia syndrome (POTS) is a chronic and often disabling disorder characterized by orthostatic intolerance with excessive heart rate increase without hypotension during upright posture. Patients often experience a constellation of other typical symptoms including fatigue, exercise intolerance and gastrointestinal distress. A typical patient with POTS is a female of child-bearing age, who often first displays symptoms in adolescence. The onset of POTS may be precipitated by immunological stressors such as a viral infection. A variety of pathophysiologies are involved in the abnormal postural tachycardia response; however, the pathophysiology of the syndrome is incompletely understood and undoubtedly multifaceted. Clinicians and researchers focused on POTS convened at the National Institutes of Health in July 2019 to discuss the current state of understanding of the pathophysiology of POTS and to identify priorities for POTS research. This article, the first of two articles summarizing the information discussed at this meeting, summarizes the current understanding of this disorder and best practices for clinical care. The evaluation of a patient with suspected POTS should seek to establish the diagnosis, identify co-morbid conditions, and exclude conditions that could cause or mimic the syndrome. Once diagnosed, management typically begins with patient education and non-pharmacologic treatment options. Various medications are often used to address specific symptoms, but there are currently no FDA-approved medications for the treatment of POTS, and evidence for many of the medications used to treat POTS is not robust.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bourne, Kate M.University of Calgary (author)
  • Stiles, Lauren E.Dysautonomia International,Stony Brook University (author)
  • Grubb, Blair P.The University of Toledo Medical Center (author)
  • Fedorowski, ArturLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-afr (author)
  • Stewart, Julian M.New York Medical College (author)
  • Arnold, Amy C.Vanderbilt University,Pennsylvania State University (author)
  • Pace, Laura A.University of Utah (author)
  • Axelsson, JonasKarolinska University Hospital(Swepub:lu)jo0150ax (author)
  • Boris, Jeffrey R.Jeffrey R Boris MD LLC (author)
  • Moak, Jeffrey P.George Washington University (author)
  • Goodman, Brent P.Mayo Clinic Scottsdale-Phoenix, Arizona (author)
  • Chémali, Kamal R.Sentara Healthcare (author)
  • Chung, Tae H.Johns Hopkins University School of Medicine (author)
  • Goldstein, David S.National Institutes of Health, United States (author)
  • Diedrich, AndreVanderbilt University (author)
  • Miglis, Mitchell G.Stanford University (author)
  • Cortez, Melissa M.University of Utah (author)
  • Miller, Amanda J.Pennsylvania State University (author)
  • Freeman, RoyBeth Israel Deaconess Medical Center,Harvard Medical School (author)
  • Biaggioni, ItaloVanderbilt University (author)
  • Rowe, Peter C.Johns Hopkins University (author)
  • Sheldon, Robert S.University of Calgary (author)
  • Shibao, Cyndya A.Vanderbilt University (author)
  • Systrom, David M.Harvard Medical School (author)
  • Cook, Glen A.Uniformed Services University of the Health Sciences (author)
  • Doherty, Taylor A.University of California, San Diego (author)
  • Abdallah, Hasan I.Children's Heart Institute (author)
  • Darbari, AnilGeorge Washington University (author)
  • Raj, Satish R.University of Calgary (author)
  • University of Texas Southwestern Medical CenterUniversity of Calgary (creator_code:org_t)

Related titles

  • In:Autonomic Neuroscience: Basic and Clinical: Elsevier BV2351566-0702

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