The complex genetics of gait speed : Genome-wide meta-analysis approach

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Ben-Avraham, DanYeshiva University (author)

The complex genetics of gait speed : Genome-wide meta-analysis approach

Article/chapterEnglish2017

Publisher, publication year, extent ...

2017-01-10
Impact Journals, LLC,2017
38 s.

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:2a540d9f-73ba-41d7-8442-fe16f20afb72
https://lup.lub.lu.se/record/2a540d9f-73ba-41d7-8442-fe16f20afb72URI
https://doi.org/10.18632/aging.101151DOI
https://gup.ub.gu.se/publication/256363URI

Supplementary language notes

Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consortium, and validated our results in 2,588 older adults from 4 independent studies. We followed our initial discoveries with network and eQTL analysis of candidate signals in tissues. The meta-analysis resulted in a list of 536 suggestive genome wide significant SNPs in or near 69 genes. Further interrogation with Pathway Analysis placed gait speed as a polygenic complex trait in five major networks. Subsequent eQTL analysis revealed several SNPs significantly associated with the expression of PRSS16, WDSUB1 and PTPRT, which in addition to the meta-analysis and pathway suggested that genetic effects on gait speed may occur through synaptic function and neuronal development pathways. No genome-wide significant signals for gait speed were identified from this moderately large sample of older adults, suggesting that more refined physical function phenotypes will be needed to identify the genetic basis of gait speed in aging.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
Aging
Gait speed
GWAS
Meta-analysis

Added entries (persons, corporate bodies, meetings, titles ...)

Karasik, DavidBar-Ilan University,Beth Israel Deaconess Medical Center (author)
Verghese, JoeYeshiva University (author)
Lunetta, Kathryn LBoston University,National Heart Lung and Blood Institute (author)
Smith, Jennifer AUniversity of Michigan (author)
Eicher, John D.National Heart Lung and Blood Institute (author)
Vered, RotemUniversity of Haifa (author)
Deelen, JorisMax Planck Institute for Biology of Ageing,Leiden University Medical Centre (author)
Arnold, Alice MUniversity of Washington (author)
Buchman, Aron SRush University Medical Center Chicago (author)
Tanaka, ToshikoNational Institute on Aging, United States (author)
Faul, Jessica DUniversity of Michigan (author)
Nethander, Maria,1980Gothenburg University,Göteborgs universitet,University of Gothenburg,Core Facilities, Bioinformatics,Core Facilities, Bioinformatics(Swepub:gu)xnetma (author)
Fornage, MyriamUniversity of Texas (author)
Adams, Hieab H.Erasmus University Medical Center (author)
Matteini, Amy M.Johns Hopkins University (author)
Callisaya, Michele L.Peninsula Health,University of Tasmania (author)
Smith, Albert VUniversity of Iceland (author)
Yu, LeiRush University Medical Center Chicago (author)
De Jager, Philip LBrigham and Women's Hospital / Harvard Medical School,Harvard University,Broad Institute (author)
Evans, Denis ARush University Medical Center Chicago (author)
Gudnason, VilmundurUniversity of Iceland (author)
Hofman, AlbertErasmus University Medical Center,Harvard University (author)
Pattie, AlisonUniversity of Edinburgh (author)
Corley, JanieUniversity of Edinburgh (author)
Launer, Lenore J.National Institute on Aging, United States (author)
Knopman, Davis S.Mayo Clinic Minnesota (author)
Parimi, NeetaCalifornia Pacific Medical Center (author)
Turner, Stephen T.Mayo Clinic Minnesota (author)
Bandinelli, StefaniaAzienda Sanitaria Firenze (ASF) (author)
Beekman, MarianLeiden University Medical Centre (author)
Gutman, DanielleUniversity of Haifa (author)
Sharvit, LitalUniversity of Haifa (author)
Mooijaart, Simon PLeiden University Medical Centre (author)
Liewald, David C MUniversity of Edinburgh (author)
Houwing-Duistermaat, Jeanine JLeiden University Medical Centre,University of Leeds (author)
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,University of Gothenburg,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl (author)
Moed, MatthijsLeiden University Medical Centre (author)
Verlinden, Vincent J.Erasmus University Medical Center (author)
Mellström, Dan,1945Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xmelda (author)
van der Geest, Jos N.Erasmus University Medical Center (author)
Karlsson, MagnusLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-mka (author)
Hernandez, DenaNational Institute on Aging, United States (author)
McWhirter, RebekahUniversity of Tasmania (author)
Liu, YongmeiWake Forest University (author)
Thomson, RussellUniversity of Tasmania,Western Sydney University (author)
Tranah, Gregory JCalifornia Pacific Medical Center (author)
Uitterlinden, Andre G.Erasmus University Medical Center (author)
Weir, David RUniversity of Michigan (author)
Zhao, WeiUniversity of Michigan (author)
Starr, John MUniversity of Edinburgh (author)
Johnson, Andrew DNational Heart Lung and Blood Institute (author)
Arfan Ikram, M.Erasmus University Medical Center (author)
Bennett, David ARush University Medical Center Chicago (author)
Cummings, Steven RCalifornia Pacific Medical Center (author)
Deary, Ian JUniversity of Edinburgh (author)
Harris, Tamara B.National Institute on Aging, United States (author)
Kardia, Sharon L.University of Michigan (author)
Mosley, Thomas H.University of Mississippi Medical Center (author)
Srikanth, Velandai K.University of Tasmania,Peninsula Health (author)
Windham, Beverly G.University of Mississippi Medical Center (author)
Newman, Ann B.University of Pittsburgh (author)
Walston, Jeremy D.Johns Hopkins University (author)
Davies, GailUniversity of Edinburgh (author)
Evans, Daniel SCalifornia Pacific Medical Center (author)
Slagboom, P. ElineLeiden University Medical Centre (author)
Ferrucci, LuigiNational Institute on Aging, United States (author)
Kiel, Douglas PBroad Institute,Beth Israel Deaconess Medical Center (author)
Murabito, Joanne M.Boston University,National Heart Lung and Blood Institute (author)
Atzmon, GilUniversity of Haifa,Yeshiva University (author)
Yeshiva UniversityBar-Ilan University (creator_code:org_t)

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In:Aging: Impact Journals, LLC9:1, s. 209-2461945-4589

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By the author/editor: Ben-Avraham, Dan; Karasik, David; Verghese, Joe; Lunetta, Kathryn ...; Smith, Jennifer ...; Eicher, John D.; show more...; Vered, Rotem; Deelen, Joris; Arnold, Alice M; Buchman, Aron S; Tanaka, Toshiko; Faul, Jessica D; Nethander, Maria ...; Fornage, Myriam; Adams, Hieab H.; Matteini, Amy M.; Callisaya, Miche ...; Smith, Albert V; Yu, Lei; De Jager, Philip ...; Evans, Denis A; Gudnason, Vilmun ...; Hofman, Albert; Pattie, Alison; Corley, Janie; Launer, Lenore J ...; Knopman, Davis S ...; Parimi, Neeta; Turner, Stephen ...; Bandinelli, Stef ...; Beekman, Marian; Gutman, Danielle; Sharvit, Lital; Mooijaart, Simon ...; Liewald, David C ...; Houwing-Duisterm ...; Ohlsson, Claes, ...; Moed, Matthijs; Verlinden, Vince ...; Mellström, Dan, ...; van der Geest, J ...; Karlsson, Magnus; Hernandez, Dena; McWhirter, Rebek ...; Liu, Yongmei; Thomson, Russell; Tranah, Gregory ...; Uitterlinden, An ...; Weir, David R; Zhao, Wei; Starr, John M; Johnson, Andrew ...; Arfan Ikram, M.; Bennett, David A; Cummings, Steven ...; Deary, Ian J; Harris, Tamara B ...; Kardia, Sharon L ...; Mosley, Thomas H ...; Srikanth, Veland ...; Windham, Beverly ...; Newman, Ann B.; Walston, Jeremy ...; Davies, Gail; Evans, Daniel S; Slagboom, P. Eli ...; Ferrucci, Luigi; Kiel, Douglas P; Murabito, Joanne ...; Atzmon, Gil; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Geriatrics

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