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  • Stepien, MagdalenaInternational Agency for Research on Cancer, World Health Organization (author)

Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-02-02
  • Springer Science and Business Media LLC,2017
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:2a6cada5-4721-413b-a436-b6e078744128
  • https://lup.lub.lu.se/record/2a6cada5-4721-413b-a436-b6e078744128URI
  • https://doi.org/10.1038/bjc.2017.1DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133525URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135302690URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.METHODS: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk.RESULTS: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13-0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45-2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41-15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed.CONCLUSIONS: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hughes, David JRoyal College of Surgeons in Ireland (author)
  • Hybsier, SandraCharité - University Medicine Berlin (author)
  • Bamia, ChristinaHellenic Health Foundation, Athens,National and Kapodistrian University of Athens (author)
  • Tjønneland, AnneDanish Cancer Society (author)
  • Overvad, KimAarhus University (author)
  • Affret, AurélieInstitut Gustave Roussy,University of Paris-Saclay (author)
  • His, MathildeUniversity of Paris-Saclay,Institut Gustave Roussy (author)
  • Boutron-Ruault, Marie-ChristineInstitut Gustave Roussy,University of Paris-Saclay (author)
  • Katzke, VerenaGerman Cancer Research Centre (author)
  • Kühn, TilmanGerman Cancer Research Centre (author)
  • Aleksandrova, Krasimira (author)
  • Trichopoulou, Antonia (author)
  • Lagiou, Pagona (author)
  • Orfanos, Phlippos (author)
  • Palli, Domenico (author)
  • Sieri, Sabina (author)
  • Tumino, Rosario (author)
  • Ricceri, Fulvio (author)
  • Panico, Salvatore (author)
  • Bueno-de-Mesquita, H B As (author)
  • Peeters, Petra H (author)
  • Weiderpass, ElisabeteKarolinska Institutet (author)
  • Lasheras, Cristina (author)
  • Bonet Bonet, Catalina (author)
  • Molina-Portillo, Elena (author)
  • Dorronsoro, Miren (author)
  • Huerta, José María (author)
  • Barricarte, Aurelio (author)
  • Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-boh (author)
  • Sjöberg, KlasLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-ksj (author)
  • Werner, MårtenUmeå universitet,Umeå University,Medicin(Swepub:umu)manwer04 (author)
  • Shungin, DmitryUmeå universitet,Umeå University,Institutionen för odontologi,Medicin(Swepub:lu)med-dsn (author)
  • Wareham, Nick (author)
  • Khaw, Kay-Tee (author)
  • Travis, Ruth C (author)
  • Freisling, Heinz (author)
  • Cross, Amanda JInternational Agency for Research on Cancer, World Health Organization (author)
  • Schomburg, Lutz (author)
  • Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization (author)
  • International Agency for Research on Cancer, World Health OrganizationRoyal College of Surgeons in Ireland (creator_code:org_t)

Related titles

  • In:British Journal of Cancer: Springer Science and Business Media LLC116:5, s. 688-6961532-18270007-0920

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