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Release of endothel...
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Andersson, SvenLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
(författare)
Release of endothelin-1 into rat airways following Sephadex-induced inflammation; modulation by enzyme inhibitors and budesonide
- Artikel/kapitelEngelska1996
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LIBRIS-ID:oai:lup.lub.lu.se:2b2e5f37-0f36-4ef3-b1d6-30c57eafb13c
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https://lup.lub.lu.se/record/1111108URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1931920URI
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https://doi.org/10.1159/000196528DOI
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Språk:engelska
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Sammanfattning på:engelska
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The intratracheal (i.t.) instillation of Sephadex beads into rat induced inflammation and a 30-fold increase in the endothelin-1-like immunoreactivity (ET-1-LI) of broncho-alveolar lavage fluid. The levels were highest 24 h after the instillation and had declined significantly after 48 h. At a dose of 1 mg kg-1 i.t., the glucocorticosteroid budesonide almost abolished this response. Phosphoramidon, which inhibits neutral endopeptidase, an enzyme reported to degrade ET-1 and also to inhibit the endothelin-converting enzyme, potentiated the Sephadex-induced rise in ET-1-LI. Chymostatin and heparin, which are reported to reduce the formation of ET-1, did not affect the increase in ET-1-LI. The present model represents a very reactive system for analyzing the changes in ET-1 levels during inflammation.
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Hemsen, A
(författare)
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Zackrisson, C
(författare)
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Lundberg, J M
(författare)
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Medicin, LundSektion II
(creator_code:org_t)
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Ingår i:Respiration: S. Karger AG63:2, s. 111-1161423-03560025-7931
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