Search: WFRF:(Schultze Joachim L.) >
Aberrant chromatin ...
Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation
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- Gerber, Julia P. (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,UCL Cancer Institute
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- Russ, Jenny (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Chandrasekar, Vijay (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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show more...
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- Offermann, Nina (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Lee, Hang Mao (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Spear, Sarah (author)
- Queen Mary University
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- Guzzi, Nicola (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine
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- Maida, Simona (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Pattabiraman, Sundararaghavan (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Zhang, Ruoyu (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Kayvanjoo, Amir H. (author)
- University of Bonn
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- Datta, Preeta (author)
- UCL Cancer Institute
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- Kasturiarachchi, Jagath (author)
- UCL Cancer Institute
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- Sposito, Teresa (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Izotova, Natalia (author)
- UCL Cancer Institute
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- Händler, Kristian (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Adams, Peter D. (author)
- Sanford Burnham Prebys Medical Discovery Institute
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- Marafioti, Teresa (author)
- University College London,UCL Cancer Institute
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- Enver, Tariq (author)
- UCL Cancer Institute
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- Wenzel, Jörg (author)
- University Hospital Bonn
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- Beyer, Marc (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Mass, Elvira (author)
- University of Bonn
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- Bellodi, Cristian (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,RNA och stamcellsbiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,RNA and Stem Cell Biology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Schultze, Joachim L. (author)
- University of Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Capasso, Melania (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Queen Mary University
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- Nimmo, Rachael (author)
- UCL Cancer Institute
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- Salomoni, Paolo (author)
- UCL Cancer Institute,German Center for Neurodegenerative Diseases (DZNE), Bonn
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(creator_code:org_t)
- 2021-12-07
- 2021
- English 16 s.
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In: Nature Cell Biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 23:12, s. 1224-1239
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukaemia and other neoplasms, in protection from inflammatory disease. Loss of Daxx alters the chromatin landscape, H3.3 distribution and histone marks of haematopoietic progenitors, leading to engagement of a Pu.1-dependent transcriptional programme for myelopoiesis at the expense of B-cell differentiation. This causes neutrophilia and inflammation, predisposing mice to develop an autoinflammatory skin disease. While these molecular and phenotypic perturbations are in part reverted in animals lacking both Pu.1 and Daxx, haematopoietic progenitors in these mice show unique chromatin and transcriptome alterations, suggesting an interaction between these two pathways. Overall, our findings implicate retrotransposable element silencing in haematopoiesis and suggest a cross-talk between the H3.3 loading machinery and the pioneer transcription factor Pu.1.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Gerber, Julia P.
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Russ, Jenny
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Chandrasekar, Vi ...
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Offermann, Nina
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Lee, Hang Mao
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Spear, Sarah
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show more...
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Guzzi, Nicola
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Maida, Simona
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Pattabiraman, Su ...
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Zhang, Ruoyu
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Kayvanjoo, Amir ...
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Datta, Preeta
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Kasturiarachchi, ...
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Sposito, Teresa
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Izotova, Natalia
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Händler, Kristia ...
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Adams, Peter D.
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Marafioti, Teres ...
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Enver, Tariq
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Wenzel, Jörg
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Beyer, Marc
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Mass, Elvira
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Bellodi, Cristia ...
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Schultze, Joachi ...
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Capasso, Melania
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Nimmo, Rachael
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Salomoni, Paolo
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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Nature Cell Biol ...
- By the university
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Lund University