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Frataxin deficiency...
Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass
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- Ristow, Michael (author)
- Free University of Berlin,German Institute of Human Nutrition
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- Mulder, Hindrik (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
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- Pomplun, Doreen (author)
- Free University of Berlin,German Institute of Human Nutrition
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- Schulz, Tim J. (author)
- Free University of Berlin,German Institute of Human Nutrition
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- Müller-Schmehl, Katrin (author)
- German Institute of Human Nutrition
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- Krause, Anja (author)
- German Institute of Human Nutrition
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- Fex, Malin (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
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- Puccio, Hélène (author)
- IGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire
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- Müller, Jörg (author)
- Magnettech GmbH
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- Isken, Frank (author)
- German Institute of Human Nutrition,Free University of Berlin
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- Spranger, Joachim (author)
- Free University of Berlin,German Institute of Human Nutrition
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- Müller-Wieland, Dirk (author)
- German Diabetes Research Institute
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- Magnuson, Mark A. (author)
- Vanderbilt University
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- Möhlig, Matthias (author)
- German Institute of Human Nutrition,Free University of Berlin
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- Koenig, Michel (author)
- IGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire
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- Pfeiffer, Andreas F.H. (author)
- German Institute of Human Nutrition,Free University of Berlin
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Journal of Clinical Investigation. - 0021-9738. ; 112:4, s. 527-534
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http://dx.doi.org/10... (free)
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Abstract
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- Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing β cells. We have disrupted expression of the mitochondrial protein frataxin selectively in pancreatic β cells. Mice were born healthy but subsequently developed impaired glucose tolerance progressing to overt diabetes mellitus. These observations were explained by impairment of insulin secretion due to a loss of β cell mass in knockout animals. This phenotype was preceded by elevated levels of reactive oxygen species in knockout islets, an increased frequency of apoptosis, and a decreased number of proliferating β cells. Hence, disruption of the frataxin gene in pancreatic β cells causes diabetes following cellular growth arrest and apoptosis, paralleled by an increase in reactive oxygen species in islets. These observations might provide insight into the deterioration of β cell function observed in different subtypes of diabetes in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ristow, Michael
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Mulder, Hindrik
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Pomplun, Doreen
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Schulz, Tim J.
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Müller-Schmehl, ...
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Krause, Anja
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show more...
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Fex, Malin
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Puccio, Hélène
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Müller, Jörg
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Isken, Frank
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Spranger, Joachi ...
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Müller-Wieland, ...
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Magnuson, Mark A ...
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Möhlig, Matthias
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Koenig, Michel
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Pfeiffer, Andrea ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Lund University