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  • Kiiski, Johanna I.Helsinki University Central Hospital (author)

FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-07-12
  • Springer Science and Business Media LLC,2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:2bf1236e-9d4b-43a8-a82a-13c54694698d
  • https://lup.lub.lu.se/record/2bf1236e-9d4b-43a8-a82a-13c54694698dURI
  • https://doi.org/10.1007/s10549-017-4388-0DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Purpose: The FANCM c.5101C>T nonsense mutation was previously found to associate with breast cancer in the Finnish population, especially among triple-negative cases. Here, we studied the prevalence of three other FANCM variants: c.5791C>T, which has been reported to predispose to familial breast cancer, and the c.4025_4026delCT and c.5293dupA variants recently identified in Finnish cancer patients. Methods: We genotyped the FANCM c.5791C>T mutation in 4806 invasive breast cancer patients, including BRCA1/2 mutation negative familial cases and unselected cases, and in 2734 healthy population controls from four different geographical areas of Finland. The association of the mutation with breast cancer risk among patient subgroups was statistically evaluated. We further analyzed the combined risk associated with c.5101C>T and c.5791C>T mutations. We also genotyped 526 unselected ovarian cancer patients for the c.5791C>T mutation and 862 familial breast cancer patients for the c.4025_4026delCT and c.5293dupA variants. Results: The frequency of the FANCM c.5791C>T mutation was higher among breast cancer cases than in controls (OR 1.94, 95% CI 0.87–4.32, P = 0.11), with a statistically significant association with triple-negative breast cancer (OR 5.14, 95% CI 1.65–16.0, P = 0.005). The combined analysis for c.5101C>T and c.5791C>T carriers confirmed a strong association with breast cancer (OR 1.86, 95% CI 1.32–2.49, P = 0.0002), especially among the triple-negative patients (OR 3.08, 95% CI 1.77–5.35, P = 0.00007). For the other variants, only one additional c.4025_4026delCT carrier and no c.5293dupA carriers were observed. Conclusions: These results support the role of FANCM as a breast cancer susceptibility gene, particularly for triple-negative breast cancer.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tervasmäki, AnnaUniversity of Oulu (author)
  • Pelttari, Liisa MHelsinki University Central Hospital (author)
  • Khan, SofiaHelsinki University Central Hospital (author)
  • Mantere, TuomoUniversity of Oulu (author)
  • Pylkäs, KatriUniversity of Oulu (author)
  • Mannermaa, ArtoKuopio University Hospital,University of Eastern Finland (author)
  • Tengström, MariaKuopio University Hospital (author)
  • Kvist, AndersLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups(Swepub:lu)ekol-akv (author)
  • Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups(Swepub:lu)onk-abo (author)
  • Kosma, Veli-MattiUniversity of Eastern Finland,Kuopio University Hospital (author)
  • Kallioniemi, AnneUniversity of Tampere (author)
  • Schleutker, JohannaTurku University Hospital,University of Turku (author)
  • Bützow, RalfHelsinki University Central Hospital (author)
  • Blomqvist, CarlHelsinki University Central Hospital (author)
  • Aittomäki, KristiinaHelsinki University Central Hospital (author)
  • Winqvist, RobertUniversity of Oulu (author)
  • Nevanlinna, HeliHelsinki University Central Hospital (author)
  • Helsinki University Central HospitalUniversity of Oulu (creator_code:org_t)

Related titles

  • In:Breast Cancer Research and Treatment: Springer Science and Business Media LLC166:1, s. 217-2260167-68061573-7217

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